ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 0376

Higher Intake of Carbohydrates and Free Sugar Are Associated with Higher Disease Activity in Patients with Axial Spondyloarthritis

Valeria Rios Rodriguez1, Marina D'Urso1, Caroline Höppner1, Fabian Proft1, Mikhail Protopopov1, Judith Rademacher1, Burkhard Muche1, Susanne Lüders1, Hildrun Haibel1, Maryna Verba1, Joachim Sieper1 and Denis Poddubnyy2, 1Charité Universitätsmedizin Berlin, Berlin, Germany, 2Charité – Universitätsmedizin Berlin, Berlin, Germany

Meeting: ACR Convergence 2020

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Date: Friday, November 6, 2020

Title: Spondyloarthritis Including Psoriatic Arthritis – Treatment Poster I

Session Type: Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Diet has been described as a factor influencing the course of rheumatic diseases, such as rheumatoid arthritis and systemic lupus erythematosus (SLE). In addition, it has been previously reported that dietary sugar intake may contribute to subclinical inflammation and disease activity in SLE. However, no studies have been performed to investigate the possible association of nutritional parameters on disease activity in patients with spondyloarthritis (SpA).

Methods: Patients with radiographic axSpA (ankylosing spondylitis fulfilling the modified New York criteria) and starting a bDMARD therapy were recruited between 2015 and 2019 in an extension of the prospective German Spondyloarthritis Inception Cohort (GESPIC). Dietary habits were collected at baseline using the country-specific validated food frequency questionnaire (FFQ) developed for the use in the German Health examination Survey for Adults 2008-2011. The FFQ includes questions about the frequency and amount of 53 food items, consumed during the past 4 weeks, and enabled to compute individual mean consumptions of foods in grams per day. Total energy intake (in Kcal per day) and nutritional parameters: carbohydrates, free sugars, total fats, saturated fats, mono and poly-unsaturated fats, proteins and dietary fiber, were calculated for each patient using Prodi® software (version 6.10, Basis, Nutri-Science, Stuttgart/Germany) and the database of Federal Food Code (Bundeslebensmittelschlüssel), version 3.02. Disease activity measures (BASDAI, CRP and ASDAS), as well as height, weight and body mass index (BMI) were assessed at baseline before bDMARD treatment.

Results: A total of 129 patients with axSpA were included in this cohort. FFQ with the consequent nutritional analysis was performed in 104 patients. There were 68.3% males, and 86.5% were HLA-B27 positive. At baseline, patients presented BMI of 25.1±4.3 kg/m2, BASDAI 5.6±1.4, CRP 14.0±18.2 mg/l, and ASDAS 3.5±1.0.

In the univariable analysis, a higher energy intake and carbohydrates at baseline were associated with higher disease activity, measured by ASDAS, BASDAI and CRP (tables 1-3). This association was attributable to the full intake of carbohydrates and specifically to the total of free sugars (monosaccharides and disaccharides) and the decrease of dietary fiber as shown in the multivariable analyses (tables 1-3). This effect was independent of age, sex, smoker status and BMI.

Conclusion: A higher intake of carbohydrates and a higher consumption of free sugars are associated with higher disease activity in patients with AS.

Table 1. Univariable and multivariable linear regression analysis of the association between ASDAS and nutritional parameters in patients with radiographic axial SpA (n=104)

Table 2. Univariable and multivariable linear regression analysis of the association between BASDAI and nutritional parameters in patients with radiographic axial SpA (n=104)

Table 3. Univariable and multivariable linear regression analysis of the association between CRP and nutritional parameters in patients with radiographic axial SpA (n=104)


Disclosure: V. Rios Rodriguez, None; M. D'Urso, None; C. Höppner, None; F. Proft, Novartis, 2, 8, AbbVie, 8, AMGEN, 8, BMS, 8, Hexal, 8, Celgene, 8, Lilly, 8, MSD, 8, Pfizer, 8, Roche, 8, UCB, 8; M. Protopopov, None; J. Rademacher, None; B. Muche, None; S. Lüders, None; H. Haibel, None; M. Verba, None; J. Sieper, AbbVie, 5, Novartis, 5, 8, Lilly, 8, Janssen, 5, Merck, 5, 8; D. Poddubnyy, Eli Lilly and Company, 2, 5, 8, MSD, 2, 5, 8, Novartis, 2, 5, 8, Pfizer, 2, 5, 8, BioCad, 5, Gilead, 5, GSK, 5, UCB, 5, 8, BMS, 8.

To cite this abstract in AMA style:

Rios Rodriguez V, D'Urso M, Höppner C, Proft F, Protopopov M, Rademacher J, Muche B, Lüders S, Haibel H, Verba M, Sieper J, Poddubnyy D. Higher Intake of Carbohydrates and Free Sugar Are Associated with Higher Disease Activity in Patients with Axial Spondyloarthritis [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/higher-intake-of-carbohydrates-and-free-sugar-are-associated-with-higher-disease-activity-in-patients-with-axial-spondyloarthritis/. Accessed .
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to ACR Convergence 2020

ACR Meeting Abstracts - https://acrabstracts.org/abstract/higher-intake-of-carbohydrates-and-free-sugar-are-associated-with-higher-disease-activity-in-patients-with-axial-spondyloarthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology