Session Information
Date: Sunday, November 13, 2016
Title: Vasculitis - Poster I: Large Vessel Vasculitis and Polymyalgia Rheumatica
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: We aimed to determine the prevalence of overweight, obesity and metabolic syndrome (MetS) and leptin levels in patients with Takayasu arteritis (TA) and their associations with disease activity.
Methods: This cross-sectional study included 32 patients with TA followed up at a Rheumatology clinic of a university hospital. 25 age- and gender-matched patients with systemic lupus erythematosus (SLE) were enrolled as controls. According to the TA follow-up protocol of the Rheumatology and Radiology Board of our hospital, the patients were followed using 3-6 monthly B-mode/Doppler USG examinations and 6-12 monhtly magnetic resonance angiography (MRA). Disease activity was assessed by using the Indian Takayasu Clinical Activity Score 2010-A (ITAS2010-A), radiological activity parameters, and acute-phase reactants (AFR). We used carotid intima media thickness (IMT) measurements and the presence of atheromatous plaques in carotid arteries as indicators of atherosclerosis. We also searched serum leptin and ghrelin levels and their relationship with obesity, overweight and MetS in Takayasu patients.
Results: 32 patients (28 females; mean age: 43 years) who fulfilled the American College of Rheumatology (ACR) criteria for TA were enrolled in this study. The prevalences of overweight (body mass index (BMI) between 25 and 30 kg/m2), obesity (BMI ≥30 kg/m2) and MetS (The National Cholesterol Education Program Adult Treatment Panel III criteria), were 26.5%, 17.6% and 23.5%, respectively. These prevalences were similar in TA and SLE patients. TA patients with obesity/overweight had higher ITAS2010-A scores compared with those without obesity/overweight and those with MetS had higher radiological activity scores compared with those without MetS although they had similar AFR levels. TA patients with obesity/overweight had also higher leptin levels. The frequency of atheromatous plaque was found to be higher in patients with MetS than those without MetS although there was no difference in carotid IMTs between the groups (Table 1).
Conclusion: This study showed that TA patients had similar prevalences of obesity/overweight and MetS to those found in SLE patients. It also suggested that there was a relationship between disease activity and obesity/overweight and MetS in TA patients. TA patients with greater BMIs had also increased leptin levels.
| Table 1. Clinical and laboratory features in Takayasu patients with overweight/obesity and MetS | |||||||
|
Metabolic syndrome |
P value |
Overweight and obesity |
P value |
||||
|
(+) (n=8)
|
(-) (n=24)
|
(+) (n=15)
|
(-) (n=17)
|
||||
| ITAS2010-A | Active(n) |
1 |
4 |
>0.05 |
5 |
0 |
0.015* |
| Inactive(n) |
7 |
20 |
10 |
17 |
|||
| Radiologic activity | Active(n) |
5 |
6 |
0.04* |
6 |
5 |
>0.05 |
| Inactive(n) |
2 |
17 |
8 |
11 |
|||
| CRP (mg/L) |
11.5 |
11.4 |
>0.05 |
13.6 |
9.6 |
>0.05 |
|
| ESR (mm/h) |
35.0 |
26.0 |
>0.05 |
30.7 |
27.1 |
>0.05 |
|
| Presence of atheromatous plaque (n) |
4 |
1 |
0.04* |
3 |
2 |
>0.05 |
|
| Leptin (ng/mL) |
58 |
79 |
>0.05 |
100 |
53 |
0.05* |
|
| Ghrelin (pg/mL) |
295 |
284 |
>0.05 |
249 |
317 |
>0.05
|
|
To cite this abstract in AMA style:
Kenar G, Yarkan H, Zengin B, Can G, Birlik M, Akkoc N, Onen F. High Disease Activity Scores and Leptin Levels in Takayasu Patients with Overweight and Obesity [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/high-disease-activity-scores-and-leptin-levels-in-takayasu-patients-with-overweight-and-obesity/. Accessed .« Back to 2016 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/high-disease-activity-scores-and-leptin-levels-in-takayasu-patients-with-overweight-and-obesity/