ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 274

Frequency of Chronic Joint Pain Following Chikungunya Infection: A Colombian Cohort Study

Aileen Chang1, Liliana Encinales2, Alexandra Porras3, Nelly Pacheco2, St. Patrick Reid4, Karen Martins5, Shamila Pacheco2, Eyda Bravo2, Marianda Navarno2, Alejandro Rico Mendoza3, Richard Amdur6, Priyanka Kamalapathy6, Gary S. Firestein7, Jeffrey Bethony6 and Gary Simon6, 1Medicine, George Washington University, Washington, DC, 2Allied Research Society, Baranquilla, Colombia, 3Allied Research Society, Bogota, Colombia, 4University of Nebraska, Omaha, NE, 5United States Army Medical Research Institute of Infectious Disease, Frederick, MD, 6George Washington University, Washington, DC, 7Medicine, University of California San Diego, La Jolla, CA

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords:

Session Information

Date: Sunday, November 5, 2017

Title: Infection-related Rheumatic Disease Poster

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: To estimate the frequency of chronic joint pain after infection with chikungunya virus in a Latin American cohort.

Methods: A cross sectional follow-up of a prospective cohort of 500 Chikungunya patients from Atlántico Department, Colombia clinically diagnosed with chikungunya during the 2014-2015 Colombian epidemic. Baseline and follow-up (20-months) symptoms were evaluated in serologically confirmed cases.

Results: Among 500 patients enrolled, 485 cases were serologically confirmed with chikungunya. Patients were predominantly adults (age 49 ± 16 years), female, had a high school or less level of education and were of mestizo ethnicity. The most commonly affected joints were the small joints including the wrists, ankles and fingers. The initial joint pain lasted a median of 4 days (IQR 3-8). Sixteen percent of participants reported missing a median of 4 days (IQR 2-7) of school or work. After 20-months, one fourth of the participants had persistent joint pain. A multivariate analysis indicated that significant predictors of persistent joint pain included college graduate status, initial symptoms of headache or knee pain, missed work, normal activities affected, 4 or more days of initial symptoms, and 4 or more weeks of initial pain.

Conclusion: This is the first report to describe the frequency of chikungunya-related arthritis in the Americas after a 20-month follow-up. The high frequency of chronic disease highlights the importance of development of prevention and treatment interventions.

Disclosure: A. Chang, None; L. Encinales, None; A. Porras, None; N. Pacheco, None; S. P. Reid, None; K. Martins, None; S. Pacheco, None; E. Bravo, None; M. Navarno, None; A. Rico Mendoza, None; R. Amdur, None; P. Kamalapathy, None; G. S. Firestein, Janssen Pharmaceutica Product, L.P., 2; J. Bethony, None; G. Simon, None.

To cite this abstract in AMA style:

Chang A, Encinales L, Porras A, Pacheco N, Reid SP, Martins K, Pacheco S, Bravo E, Navarno M, Rico Mendoza A, Amdur R, Kamalapathy P, Firestein GS, Bethony J, Simon G. Frequency of Chronic Joint Pain Following Chikungunya Infection: A Colombian Cohort Study [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/frequency-of-chronic-joint-pain-following-chikungunya-infection-a-colombian-cohort-study/. Accessed .

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