Familial Mediterranean Fever Associated Infertility and Underlying Factors with Fertility

Nuh Atas¹, Berkan Armagan², Erdal Bodakci³, Timucin Kasifoglu⁴, Hasan Satis¹, Alper Sari², Nazife Sule Yasar Bilge³, Hakan Babaoglu¹, Gozde Yardımcı², Reyhan Salman¹, Levent Kilic², Abdurrahman Tufan¹, Mehmet Akif Ozturk¹, Berna Goker¹, Seminur Haznedaroglu¹ and Umut Kalyoncu², ¹Internal Medicine-Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey, ²Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ³Rheumatology, Eskisehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey, ⁴Department of Internal Medicine, Division of Rheumatology, Eskisehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Familial Mediterranean fever and fertility

Session Information

Date: Tuesday, October 23, 2018

Title: Reproductive Issues in Rheumatic Disorders Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Familial Mediterranean Fever (FMF) is the most frequent auto-inflammatory disease caused by MEFV gene mutations. Although disease is characterized by intermittent febrile inflammatory attacks of serositis and arthritis some patients may experience complications of disease. Infertility/subfertility is a complication of auto-inflammatory diseases and data is still unclear about FMF associated infertility. The aim of study is to investigate the frequency and possible underlying factors of FMF associated infertility/subfertility.

Methods:

All patients recruited from FMF in Central Anatolia (FiCA) cohort. All patients fulfilled Tel Hashomer criteria and all were using colchicine for at least 1 year. Demographic data, FMF attacks and mutation (if available) characteristics, amyloidosis and treatment features were recorded. For this study data on 403 eligible patients (mean age 41.4±10.7, 68.7% female) who had been willing to have children were used.

Results:

Proportions of FMF manifestations were fever 83.1%, peritonitis 89.6%, pleuritis 51.4%, arthritis 43.4% and skin rash 28%. MEFV mutations were available for 317 subjects and 77.9% of subjects harboring M694V mutation (27.4% homozygous for M694V). Among all 42 (10.4%) patients were colchicine non-responders. Infertility was present in 45 (11.2%) of patients. Of these 38 (13.7% of females) were female, 7 (5.6% of males) were male. Female sex (odds ratio, 2.9; 95% confidence interval, 1.07–7.98) and colchicine nonresponse (odds ratio, 4,14; 95% confidence interval, 1.75–9.78) were found to be the independent predictors of infertility.

Conclusion:

Colchicine nonresponse and female sex were found to be the independent predictors of infertility and effective therapeutic interventions may help to increase fertility in these patients.

Disclosure: N. Atas, None; B. Armagan, None; E. Bodakci, None; T. Kasifoglu, None; H. Satis, None; A. Sari, None; N. S. Yasar Bilge, None; H. Babaoglu, None; G. Yardımcı, None; R. Salman, None; L. Kilic, None; A. Tufan, None; M. A. Ozturk, None; B. Goker, None; S. Haznedaroglu, None; U. Kalyoncu, None.

To cite this abstract in AMA style:

Atas N, Armagan B, Bodakci E, Kasifoglu T, Satis H, Sari A, Yasar Bilge NS, Babaoglu H, Yardımcı G, Salman R, Kilic L, Tufan A, Ozturk MA, Goker B, Haznedaroglu S, Kalyoncu U. Familial Mediterranean Fever Associated Infertility and Underlying Factors with Fertility [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/familial-mediterranean-fever-associated-infertility-and-underlying-factors-with-fertility/. Accessed .

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