Factors Influencing on Health-Related Quality of Life in Female Systemic Lupus Erythematosus Patients with Fibromyalgia

Kyung Min Ko¹, Jun-Ki Min² and Su-Jin Moon³, ¹Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ²Bucheon St. Mary's Hospital, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Bucheon, Korea, Republic of (South), ³Bucheon St. Mary's Hospital, Division of rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Bucheon, Korea, Republic of (South)

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: depression, fibromyalgia, quality of life, sleep disorders and systemic lupus erythematosus (SLE)

Session Information

Date: Monday, November 6, 2017

Title: Systemic Lupus Erythematosus – Clinical Aspects and Treatment Poster II: Damage and Comorbidities

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Health-related quality of life (HRQoL) among systemic lupus erythematosus (SLE) patients is reduced, and fibromyalgia contribute to the decreased HRQoL. The objective of the present study is to evaluate the contributing factors for reduced HRQoL in female SLE patients regarding the presence of fibromyalgia.

Methods: The HRQoL measurement was made using the SF-36 and Euroqol EQ-5D. Sleep quality, fatigue severity, fibromyalgia severity, and SLE disease associated variables were measured.

Results: : The scores of HRQoL, including overall scores as well as the physical component summary (PCS) and mental component summary (MCS), were lower in female SLE patients with fibromyalgia (n = 41), than in those without fibromyalgia (n = 111). SLE patients with fibromyalgia showed higher SLE disease activity, and more severe fatigue score, depressive mood and deteriorated sleep quality, compared with patients without fibromyalgia. In SLE patients with fibromyalgia, education level, severity of SLE organ damage, fatigue severity, sleep quality, depressive mood and fibromyalgia severity were significantly correlated with EQ-5D, whereas age, income, SLE disease activity, steroid dose, and disease duration were not correlated with EQ-5D. On the other hand, education level did not show significant correlation with EQ-5D in SLE patients without fibromyalgia. Multivariate logistic regression analysis revealed that depressive mood and SLE disease activity are independent contributing factors for deteriorated HRQoL in female SLE patients with fibromyalgia. In SLE patients without fibromyalgia, sleep quality in addition to SLE disease activity and depressive mood plays as a independent predictor for poor HRQoL.

Conclusion: The quality of life in SLE patients can be improved by managing depressive mood and improving sleep quality. Physicians may need to pay more attention to sleep both in patients with fibromyalgia and in those without fibromyalgia.

Table1. Logistic regression analysis to identify the contributing factors of deteriorated HR-QoL (T1 by EQ-5D vs T2 and T3) in female SLE patients with fibromyalgia (n = 41)

Variable	Univariate linear regression analysis			Multivariate regression analysis
Variable	Exp(B)	95% CI	P value	Exp(B)	95% CI	P value
Education
<Junior high school	4.4	0.319-60.6	NS
Senior high school	12.1	1.31-111.3	<0.05
Bachelor	Reference			reference
SLICC-ACR damage index	1.895	1.002-3.583	<0.05
SELENA-SLEDAI score	1.316	1.032-1.676	<0.05	1.38	1.019-1.876	<0.05
FACIT fatigue score (<30)	3.167	0.827-12.12	0.092
PHQ9	1.22	1.068-1.393	<0.01	1.248	1.069-1.458	<0.01

Disclosure: K. M. Ko, None; J. K. Min, None; S. J. Moon, None.

To cite this abstract in AMA style:

Ko KM, Min JK, Moon SJ. Factors Influencing on Health-Related Quality of Life in Female Systemic Lupus Erythematosus Patients with Fibromyalgia [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/factors-influencing-on-health-related-quality-of-life-in-female-systemic-lupus-erythematosus-patients-with-fibromyalgia/. Accessed .

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