Session Information
Title: Systemic Lupus Erythematosus - Clinical Aspects I - Renal, Malignancy, Cardiovascular Disease
Session Type: Abstract Submissions (ACR)
Background/Purpose: Investigations of major lupus-cohorts have demonstrated cardiovascular disease to have major impact on morbidity and mortality (Am J Epidemiol 1997;145:408-15). The aim of this study was to determine the prevalence of coronary artery calcium and pattern of coronary artery calcium scores (CAC) among Danish patients with systemic lupus erythematosus (SLE).
Methods: In a population-based predominantly Caucasian cohort we recruited 84 SLE patients. To assess CAC a Toshiba 64-slice CT-scanner (Aquilion, Toshiba Medical Systems) with the following technical settings was used: gantry rotation time 450 msec, 3 mm collimation, 120 kV tube voltage and prospective gating at 75% of the R-R interval. Scan data were acquired during an inspiratory breathhold. CAC was expressed as Agatston score, that was calculated by summing-up the scores from each foci in the coronary arteries.
Results: Among the patients 91% were females, 98 % Caucasian, 2% Arabian, and mean age was 50,8 ± 14,2 yrs. In 43% coronary calcium was detected (CAC range 1 to 9725). Sixteen percent had a high CAC (>400), and 9% had an extremely high CAC (>1000). As shown in Table 1 patients with extremely high CAC had elevated BMI and were current smokers or previous smokers. Nephropathy and high SLICC scores were found in this group.
Table 1.
|
|
Coronary calciumscore >1000 |
Coronary calcium score 0-1000 |
|
No. |
8 |
76 |
|
Age, yrs, mean, SD |
64,8 ± 13,3 |
53,25 ± 10,6 |
|
Female, no. (%) |
5 (62) |
73 (96) |
|
Male, no. (%) |
3 (37) |
4 (5) |
|
BMI, kg/m2, mean, SD |
29,5 ± 5,3 |
25,44 ± 5,1 |
|
Ever smoker, no. (%) |
7 (87) |
47 (61) |
|
Hypertension, no. (%) |
7 (87) |
41 (53) |
|
Hypercholesterolemia |
5 (62) |
41 (53) |
|
Hyperglycemia, no. (%) |
2 (25) |
8 (10) |
|
Nephropathy, no. (%) |
3 (37) |
3 (3) |
|
Disease duration, yrs, mean, SD |
4 ± 1,4 |
12,8 ± 7,4 |
|
SLICC, mean, SD |
5,6 ± 3,8 |
1,7 ± 1,6 |
Conclusion: In a population-based cohort 9% had extremely high CAC. Traditional as well as SLE related CVD risk factor predominated among these patients.
Disclosure:
S. D. Kay,
None;
A. Voss,
None;
A. C. P. Diederichsen,
None;
M. K. Poulsen,
None.
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