ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2914

Examination of Psychometric Properties of the Patient-Reported Outcomes Measurement Information System Fatigue 4-Item Short Form in Psoriatic Arthritis

Patricia Katz1,2, Alexis Ogdie3, Evo Alemao4, Jayanti Mukherjee4 and Kaleb Michaud2,5, 1Forward/National Data Bank for Rheumatic Diseases, Wichita, KS, 2University of California San Francisco, San Francisco, CA, 3Hospital of the University of Pennsylvania, Philadelphia, PA, 4Bristol-Myers Squibb, Princeton, NJ, 5Rheumatology, University of Nebraska Medical Center, Omaha, NE

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords:

Session Information

Date: Wednesday, October 24, 2018

Title: 6W007 ACR Abstract: Patient Outcomes, Preferences, & Attitudes II: PROs (2910–2915)

Session Type: ACR Concurrent Abstract Session

Session Time: 9:00AM-10:30AM

Background/Purpose: PROMIS (Patient-Reported Outcomes Measurement Information System) measures have not been tested in psoriatic arthritis (PsA). We examined the reliability, validity and responsiveness of the PROMIS Fatigue (PR-FAT) 4-item short form in PsA and developed estimates of the minimally important difference (MID).

Methods: Data were from Forward/National Data Bank for Rheumatic Diseases. Participants complete questionnaires every 6 months. PR-FAT was included in five administrations. Changes were calculated for consecutive questionnaire administrations, yielding four change periods. Cronbach’s α tested internal consistency. Construct validity was assessed by examining correlations of PR-FAT with other measures of fatigue and other patient-reported outcomes. Responsiveness was examined using changes in self-rated fatigue, self-rated health and satisfaction with health as anchors, and standardized response means (SRMs) were calculated. MIDs were estimated using both anchor- and distribution-based methods.1 Anchor-based analyses used comparisons of overall health to 6 months ago (rated as much better, somewhat better, neither better nor worse, somewhat worse, much worse).2 Four sets of analyses were conducted: physician-confirmed PsA only without concomitant osteoarthritis (OA) or rheumatoid arthritis (RA) (n ranged from 60–78 in the 5 administrations) and with RA/OA (n: 102–129), and physician-confirmed PsA plus self-reported PsA without RA/OA (n: 111–148) and with RA/OA (ALL_PsA; n: 192–245).

Results: Findings were similar for all groups, so only results for ALL_PsA are shown. Table 1 shows characteristics of respondents. Cronbach’s α was ≥0.94 for each administration. Concurrent validity analyses showed high correlations with self-rated fatigue (≥0.72), moderate correlations with pain (r: 0.45–0.66) and function (r: 0.34–0.58) and significant differences among self-rated health groups (p<0.0001). In responsiveness analyses, all SRMs were >0.3. Estimates of MID are shown in Table 2.

Conclusion: PR-FAT appeared to be reliable and valid in this sample with PsA. SRMs in responsiveness analyses met the criterion generally accepted as adequate (0.3).3 The MID appears to be similar to those reported for other PROMIS scales. This information supports the use PR-FAT in PsA and provides important information to facilitate interpretation of scores.

References:

  1. Revicki D, et al. J Clin Epidemiol 2008;61:102–9.
  2. Bellamy N, et al. Arthritis Care Res 2015;67:972–80.
  3. Revicki D, et al. Health Qual Life Outcomes 2006;4:70.

Table 1. Characteristics of Respondents to July 2017 Questionnaire (N=192)

Age, years

62.2±10.7

Male, %

73.3

White, %

93.5

PsA duration, years

20.8±12.3

Comorbid OA, %

14.1

Comorbid RA, %

27.2

HAQ score

0.83±0.68

Fatigue*

4.0 ± 3.1

PROMIS® Fatigue

53.3±12.7

Data are mean ±SD unless otherwise indicated

*Numeric rating scale: 0 (no problem) to 10 (severe problem)

OA=osteoarthritis; PROMIS®=Patient-Reported Outcomes Measurement Information System; PsA=psoriatic arthritis

Table 2. MID Estimates for PROMIS® Fatigue Short-Form in PsA

Anchor-based analysis

Distribution-based analysis

ΔPROMIS

Standard error of measurement

0.20 SD

MID best estimate

Better*

Worse*

Mean

Range

Mean

Range

Better

Worse

Health compared with 6 months prior†

−3.0

1.8

2.26

2.09–2.48

2.39

2.24–2.54

−3

+2

Population mean ±SD for PROMIS Fatigue scores: 50±10. Higher scores reflect greater fatigue

*Much worse and much better excluded, per Bellamy2

†ΔPROMIS®, standard error of measurement and SD averaged over four change periods

Δ=change; MID=minimally important difference; PROMIS®=Patient-Reported Outcomes Measurement Information System; PsA=psoriatic arthritis

Disclosure: P. Katz, Bristol-Myers Squibb, 2; A. Ogdie, Novartis, Pfizer, 2,AbbVie, Amgen, Bristol-Myers Squibb, Celgene, Corrona, Lilly, Novartis, Pfizer, Takeda, 5; E. Alemao, Bristol-Myers Squibb, 1, 3; J. Mukherjee, Bristol-Myers Squibb, 1, 3; K. Michaud, University of Nebraska Medical Center and FORWARD, The National Databank for Rheumatic Diseases, 3,Rheumatology Research Foundation and Pfizer, 2.

To cite this abstract in AMA style:

Katz P, Ogdie A, Alemao E, Mukherjee J, Michaud K. Examination of Psychometric Properties of the Patient-Reported Outcomes Measurement Information System Fatigue 4-Item Short Form in Psoriatic Arthritis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/examination-of-psychometric-properties-of-the-patient-reported-outcomes-measurement-information-system-fatigue-4-item-short-form-in-psoriatic-arthritis/. Accessed .

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