Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Chikungunya (CKV) is a disease caused by an alphavirus, transmitted by mosquitoes of the genus Aedes. Is characterized by arthralgia, myalgia, arthritis and tenosynovitis.1 Anticyclic citrullinated peptide antibodies (ACPA) are considered specific markers of rheumatoid arthritis (RA). However ACPA have also been detected in patients with other types of chronic inflammatory rheumatism.2 The objective of this study is to investigate the positivity of ACPA in post-chikungunya arthritis.
This was a ambispective study, cross-sectional, with patients who were taken from the group comprised a total of 514 patients from the register of patients with musculoskeletal post-chikungunya infections in the rheumatology department of the Hospital Docente Padre Billini, from December 2013 to June 2017, 3 patients who met the classification criteria for reactive arthritis.4 at the Hospital Docente Padre Bilini, in the period December 2013 – June 2017. Inclusion criteria: Meet the criteria for reactive arthritis. Exclusion criteria: Patients under the age of 18, who have had prior joints symptoms or another diseases that explains the symptoms. ACPA was performed to the patients in the period May – June 2017 and clinical records were reviewed. The program SPSS V23.
Of a total of 514 patients, 41 patients met the criteria. 90.2% (37) was female, 46-64 years was the most frequent age range. 70.7% (29) had synovitis, of these 29 patients, 75.8% (22) had chronic stage synovitis. At the start of the study 9.7% (4) had positive ACPA and in time seroconversion to 34.1% (14). 24.3% (10) had positive rheumatoid factor (RF). 19.5% (8) had RA according to the 2012 American College of Rheumatology classification criteria for RA, of these 8 patients, the 87.5% (7) had ACPA positive. 2.4% (1) developed an undifferentiated polyarthropathy y 2.4% (1) met criteria for spondyloarthritis with axial and peripheral HLAB27 positive. 14.6% (6) increase C reactive protein and 46.3% (19) increase erythrosedimentation rate. 12.1% (5) were smokers.
34.1% (14) of 41 patients had ACPA positive over time, of these 14 patients, 57.1% (8) developed ACPA positive RA and 42.8% (6) had positive RF. This demonstrates a relationship between CKV infection arthritis clinics for the first time with musculoskeletal manifestation secondary arthritis and ACPA positivity over time, together with a high risk of developing RA.
- Loreto Horcada, M. Díaz-Calderón, C. Garrido, L. Chikungunya fever. Rheumatic manifestations of an emerging disease in Europe. Reumatol Clin 2015;11:161-4
- Caterbi, S. Bistoni, O. Alunno, A. et al. Anticyclic Citrullinated Peptide Antibodies in Patients with Rheumatic Diseases other than Rheumatoid Arthritis: Clinical or Pathogenic Significance? J Rheumatol 2015;42;1063-1064
- V. Rosario, R. Munoz-Louis, T. Valdez, et al. Chikungunya infection in the general population and in patients with rheumatoid arthritis on biological therapy. Clin Rheumatol 2015; 34 (7):1285-7.
- Sieper, J. Braun, J. Kingsley, G. Report on the fourth International workshop on reactive arthritis. Arthritis Rheum 200;43(4):720-734
To cite this abstract in AMA style:Tejada-Reyes E, Mercedes-Núñez I, Cruz-Rojas Y, Rodríguez-Bautista E, Rosario V, Peña-Blanco R, Muñoz-Louis R, Valdez-Lorie T, Alba-Fériz R. Evolution of Anti-Citrullinated Protein Antibodies in Post-Chikungunya Arthritis Patient in Dominican Republic [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/evolution-of-anti-citrullinated-protein-antibodies-in-post-chikungunya-arthritis-patient-in-dominican-republic/. Accessed February 16, 2020.
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