Evaluation of Serum Undercarboxylated Osteocalcin in Premenopausal Rheumatoid Arthritis Patients; Its Correlation with Disease Activity and Bone Mineral Density

Heba Esaily¹, Abd El Samad Al Hewala², Samar Soliman³, Eman Galbat⁴ and Dalia Abo Al- Ela⁵, ¹Physical Medicine and Rehabilitation,, Faculty of Medicine, Menoufia University, Menofia, Egypt, ²Department of Rheumatology, Faculty of Medecine, Zagazigue University, Al Sharquia, Egypt, ³Physical Medicine and Rehabilitation, Faculty of Medicine, Menoufia University, Menoufia,, Egypt, ⁴Physical Medicine and Rehabilitation, Faculty of Medicine, Menoufia University, Menoufia, Egypt, ⁵Clinical Pathology, Faculty of Medicine, Menoufia University, Menofia, Egypt

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Disease Activity, Osteoporosis and rheumatoid arthritis (RA)

Session Information

Date: Tuesday, November 10, 2015

Title: Rheumatoid Arthritis - Clinical Aspects Poster Session III

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

The role of vitamin K and undercarboxylated osteocalcin (ucOC) on BMD in RA is present. Up to our knowledge no other works have discussed the relationship between ucOC and BMD in premenopausal RA patients and its correlation with disease activity.

Methods:

Sixty Premenopausal rheumatoid arthritis female patients and thirty healthy premenopausal controls with matched age were included in this study.All were subjected to demographic data , clinical examination, Laboratory investigations:-including serum level of ucOC, disease activity assessment by DAS 28 score and bone mineral density measurement in the lumbar spine L2–4 ,hip and distal radius by dual-energy X-ray absorptimetry (DEXA) equipment.

Results:

In our study the level of ucOC was significantly higher in patients of RA than controls (p <0.001 ). BMD in patients was found to be significantly lower than controls in spine,femoral neck and distal radius areas. The most frequent osteoporotic site according to Z score was spine(16.7%) followed by femoral neck (8.3 %) then distal radius (6.7%).While the commonest osteopenic site according to (Z score ≤ -1) was spine(31.7%) followed by femoral neck (21.7 %)then (16.7% )in the distal radius. Our work showed that ucOC level was found to be high in premenopausal RA patients with higher DAS values than those with lower DAS value (p<0.001) . In our work BMD measured by DEXA scan was found to be lower with higher DAS values and vice versa.

Conclusion:

Serum level of ucOC (which is amirror of vitamin K defficency ) was found to be higher in premenopausal RA patients than control and correlated positively with disease activity and inversely with BMD measurement.

Disclosure: H. Esaily, None; A. E. S. Al Hewala, None; S. Soliman, None; E. Galbat, None; D. Abo Al- Ela, None.

To cite this abstract in AMA style:

Esaily H, Al Hewala AES, Soliman S, Galbat E, Abo Al- Ela D. Evaluation of Serum Undercarboxylated Osteocalcin in Premenopausal Rheumatoid Arthritis Patients; Its Correlation with Disease Activity and Bone Mineral Density [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/evaluation-of-serum-undercarboxylated-osteocalcin-in-premenopausal-rheumatoid-arthritis-patients-its-correlation-with-disease-activity-and-bone-mineral-density/. Accessed .

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