Background/Purpose: The EULAR Sjögren’s Syndrome Patient Reported Index(ESSPRI) is a patient-reported index designed to assess the severity of patients’ symptoms such as dryness, pain and fatigue in primary Sjögren Syndrome (pSS). Considering these symptoms are also very common in fibromyalgia (FM), the association between pSS and FM could contribute to higher scores of ESSPRI. The purpose of this study was to determine if score of ESSPRI differed between pSS patients with and without FM.

Methods: Sixty two women with pSS fulfilling the American–European Consensus Criteria (AECC) were recruited from the Rheumatology Outpatient Clinic of Hospital Universitário Cassiano Antônio de Moraes/Universidade Federal do Espírito Santo (UFES). All were submitted to American College of Rheumatology 1990 Criteria (ACR) for Fibromyalgia and submitted to ESSPRI and EULAR Sjogren’s syndrome Disease Activity Index(ESSDAI). Student’s t-test and Mann-Whitney were used to compare scores of ESSPRI between pSS patients with and without FM (p<0.05) and Pearson’s Correlation was used to correlate score of ESSPRI and ESSDAI (p <0.05).

Results: The mean of age was 49.4 ± 11.6, beginning of symptoms was 7.2 ± 5.4 years and diagnostic time was 3.0 ± 3.3 years. Sixty eight percent were non-Caucasian and 32% Caucasian. ESSPRI mean was 6.87 ± 1.97 and ESSDAI mean was 4.95 ± 6.73, indicating low activity. There was no correlation between ESSDAI score and ESSPRI score (r=0.051; p<0.696). The frequency of fibromyalgia in pSS patients was 43.5%. Stratified analysis showed that pSS patients with FM have higher score of ESSPRI than those without FM (7.35 ± 1.69 vs. 6.17 ± 2.34, p=0.028) (Table 1).

Conclusion: Fibromyalgia is a common comorbidity in pSS patients and it could raise the ESSPRI score and also could explain part of no correlation between ESSPRI and ESSDAI.

Table 1 – Descriptive statistics and score of ESSPRI between primary Sjögren Syndrome patients with and without Fibromyalgia

ESSPRI	Fibromyalgia	Median	Mean	Standard deviation	p-value
Dryness**	Yes	7.00	7.00	2.62	0.251
	No	6.00	6.15	2.92
Fatigue**	Yes	8.00	7.00	3.32	0.067
	No	6.00	5.03	4,07
Pain**	Yes	8.00	8.04	2.05	0.441
	No	8.00	7.33	2.89
Total score*	Yes	7.67	7.35	1.69	0.028***
	No	6.00	6.17	2.34

* Student’s t-test; ** Mann-Whitney test; ***p<0,05

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/eular-sjogrens-syndrome-patient-reported-index-esspri-is-increased-in-sjogrens-syndrome-patient-with-fibromyalgia/