ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 1807

Estimated Sodium and Potassium Intake Are Associated with Blood Pressure in Patients with Systemic Lupus Erythematosus

April Barnado, Annette M. Oeser, Yahua Zhang, Jens Titze, C. Michael Stein and Cecilia P. Chung, Medicine, Vanderbilt University, Nashville, TN

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Hypertension and systemic lupus erythematosus (SLE)

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Date: Monday, November 9, 2015

Title: Systemic Lupus Erythematosus - Clinical Aspects and Treatment Poster Session II

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: The prevalence
of hypertension is increased in patients with systemic lupus erythematosus
(SLE).  Sodium
(Na+) and potassium (K+) intake are modifiable
determinants of blood pressure in the general population and can be estimated
by measuring urinary Na+ and K+.  Higher Na+
and lower K+ intake, as well as a higher Na+: K+
ratio, are associated with elevated blood pressure. However, the contribution
of Na+ and K+ intake to hypertension in SLE is not
known.  We hypothesized that urinary excretion of Na+ and K+,
as an estimate of intake, are related to blood pressure in SLE.    Methods:
We
studied 178 patients with SLE and 86 control subjects frequency-matched for
age, sex, and race. First morning urine specimens were collected and urine Na+
and K+ concentrations measured by flame photometry. The Kawasaki
formula, a validated method that incorporates age, sex, height, weight, and
urinary creatinine, was used to estimate 24 hour urine Na+ and K+
excretion. Blood pressure was the average of two resting measurements. Fisher’s
exact and Mann-Whitney U tests were used to compare categorical and continuous
variables, respectively. The associations between systolic (SBP) and diastolic
blood pressures (DBP) with estimated 24 hour urinary Na+, K+,
and Na+ : K+ ratio were tested using Spearman
correlation and then modeled using linear regression adjusting for age, sex,
and race. Two-sided p values < 0.05 were significant.  

 

Results: Descriptive
variables including demographics, blood pressure, and urinary values for SLE
patients and controls are shown in Table 1. The estimated 24 hour urinary Na+
excretion was similar in SLE patients vs. controls, but the estimated 24 hour
urinary K+ excretion was significantly lower in SLE patients
compared to controls. The urinary Na+: K+ ratio
was higher in SLE patients than in controls, and this difference remained
significant when subjects taking anti-hypertensive drugs, including diuretics,
were excluded. In SLE patients, higher urinary Na+: K+
ratio was significantly associated with higher SBP [β coefficient (95% CI)
=4.01 (0.57-7.46), p=0.023] and DBP [β coefficient=4.41
(1.71-7.11), p=0.002] after adjustment for age, sex, and race. In
controls, there was no significant association with estimated 24 hour urinary Na+,
 K+, and Na+: K+ ratio
and SBP and DBP.   Conclusion:
SLE
patients had significantly lower estimated 24 hour urinary K+ and
higher estimated 24 hour urinary Na+: K+ ratio
than control subjects. The estimated 24 hour urinary Na+: K+
ratio was significantly associated with SBP and DBP in SLE patients but not in
controls.  Our studies suggest that diets with low Na+ and high K+
content may reduce the risk of hypertension in SLE patients.

  Table
1. Demographics of SLE cases and controls.

Characteristics SLE (n = 178) Controls (n = 86) P value*
Mean age (years ± standard deviation) 40.9 ± 12 41.2 ±  12 0.76  
Female sex (%) 88% 86% 0.70
Race/ethnicity (%)   Caucasian Non-Caucasian     68% 32%     72% 28% 0.67
Hypertension (%) 44% 19% < 0.001
Anti-hypertensive use (%) 36% 12% < 0.001
Mean systolic blood pressure (mm Hg) 120 ± 17   118 ± 14   0.63
Mean diastolic blood pressure (mm Hg) 73 ± 13   71 ± 10   0.21
Estimated 24 hour urinary sodium (gm) 4.2 ± 1.8   4.5 ± 2.1   0.54  
Estimated 24 hour urinary potassium (gm) 2.0 ± 0.7   2.4 ± 0.9   < 0.001  
Estimated 24 hour urinary sodium to potassium ratio 2.2 ± 0.7   1.9 ± 0.6   0.001  
*Wilcoxon
rank-sum and Fisher’s exact test for continuous and dichotomous variables,
respectively.

 


Disclosure: A. Barnado, None; A. M. Oeser, None; Y. Zhang, None; J. Titze, None; C. M. Stein, None; C. P. Chung, None.

To cite this abstract in AMA style:

Barnado A, Oeser AM, Zhang Y, Titze J, Stein CM, Chung CP. Estimated Sodium and Potassium Intake Are Associated with Blood Pressure in Patients with Systemic Lupus Erythematosus [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/estimated-sodium-and-potassium-intake-are-associated-with-blood-pressure-in-patients-with-systemic-lupus-erythematosus/. Accessed .
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2015 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/estimated-sodium-and-potassium-intake-are-associated-with-blood-pressure-in-patients-with-systemic-lupus-erythematosus/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology