Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose : Familial Mediterranean Fever (FMF) is a chronic autosomal recessive hereditary disease characterized by episodic attacks of fever and inflammation of serosal and synovial membranes. Premature development of atherosclerosis has been observed in patients with chronic inflammatory diseases such as systemic lupus erythematosis and rheumatoid arthritis. The relation between epicardial adipose tissue (EAT) volume and increased inflammatory cytokines, diastolic dysfunction, myocardial ischemia and adverse clinical outcomes has been shown. We aimed to evaluate EAT as a novel marker of atherosclerosis and its relation between carotis intima media thickness (CIMT) and inflammatory markers in patients with FMF.
Methods: Seventy-nine FMF patients who had been diagnosed according to Tel-Hashomer criteria in Rheumatology outpatient clinic of a university hospital were included in the study between May 2012 and December 2012. Twenty-six age and sex matched healthy individuals were recruited as the control group. CIMT and EAT were measured and the relation between inflammatory markers were evaluated.
Results: The EAT was thicker in patients with FMF than the control group (EAT 0.47 ± 0.13 vs 0.36 ± 0.10cm, p=0.001). CIMT was also greater in patients with FMF than the control group (0.78 ± 0.2 vs 0.68 ± 0.13 mm, p=0.24). In correlation analysis, EAT was correlated with CIMT (r=0.17, p=0.1), CRP (r=0.31, p=0.005), BMI (r=0.14, p=0.16), total cholesterol (r=0.170, p=0.086), LDL (r=0.212, p=0.035) and age (r=0.188, p=0.054). CIMT was correlated with CRP (r=0.211, p=0.05), serum creatinine (r=0.224, p=0.022), total cholesterol (r=0.231, p=0.019), LDL (r=0.219, p=0.03), triglyceride (r=0.214, p=0.03), age (r=0.453, p<0.001), serum glucose (r=0.267, p=0.022) and BMI (r=0.241, p=0.013).
In multivariate linear regression model, total cholesterol level (β: 0.399, t:2.716), CRP (β: 0.150, t: 2.139) and BMI (β: 0.431, t: 2.581) were found to be independent predictors of EAT.
Conclusion: Both EAT and CIMT were significantly greater in FMF patients than control subjects. In patients with FMF, EAT may be a novel marker of increased cardiovascular risk.
Table-1. Baseline characteristic of FMF patients and control subjects
|
FMF Patients |
Control Subjects |
P value |
|
|
Age (year) |
38.4 ± 10 |
41.5 ± 9.5 |
0.18 |
|
BMI (kg/m2) |
26.8 ± 4.9 |
28.1 ± 4.2 |
0. 20 |
|
EAT (mm) |
0.47 ± 0.13 |
0.36 ± 0.1 |
0.001 |
|
CIMT (mm) |
0.78 ± 0.2 |
0.68 ± 0.13 |
0.02 |
|
CRP (mg/dL) |
5.5 ± 2.7 |
2.8 ± 1.3 |
<0.001 |
|
ESR (mm/h) |
12.5 ± 1.4 |
5.2 ± 0.8 |
0.008 |
|
WBC (u/L) |
7.5 ± 1.8 |
6.8 ± 1.2 |
0.1 |
|
Hgb (g/dL) |
13.3 ± 2 |
14.6 ± 1.3 |
0.002 |
|
Creatinine (mg/dL) |
0.7 ± 0.2 |
0.8 ± 0.1 |
0.29 |
|
ALT (u/L) |
28 ± 17 |
25 ± 12 |
0.53 |
|
LDL (mg/dL) |
111 ± 34 |
112 ± 28 |
0.87 |
Disclosure:
A. Kucuk,
None;
Y. Solak,
None;
H. Akilli,
None;
O. Yildirim,
None;
I. Guler,
None;
R. Ucar,
None;
A. Aribas,
None;
O. Ozbek,
None;
M. Kayrak,
None;
R. Tunc,
None.
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