ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1547

Endocrine Co-Morbidities in Patients with Psoriatic Arthritis: A Population-Based Study

Devy Zisman1,2, Ron Ilan Ashkenazi3, Haim Bitterman4,5, Guy Shallom6, Ilan Feldhamer6, Idit Lavi7, Sari Greenberg-Dotan6 and Arnon-Dov Cohen6, 1Dept of Internal Medicine, Carmel Medical Center, Haifa, Israel, 2The Ruth and Bruce Rappaport Faculty of Medicine, Haifa, Israel, 3Carmel Medical Center, Haifa, Israel, 4Chief Physician's Office, Clalit Health Services, Haifa, Israel, 5Technion, The Ruth and Bruce Rappaport Faculty of Medicine, Haifa, Israel, 6Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel, 7Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords:

Session Information

Title: Spondyloarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment II

Session Type: Abstract Submissions (ACR)

Background/Purpose:

Co-morbidities associated with psoriatic arthritis (PsA) include cardiovascular, ophthalmic and gastrointestinal diseases. The aim of the study was to investigate endocrine co-morbidities in patients with psoriatic arthritis.

Methods:

A cross-sectional study was performed in the database of Clalit Health Services, the largest healthcare provider in Israel, between 2000 and 2013. Patients with a diagnosis of PsA were identified (study group). For each of these patients, ten patients matched for age and gender, without a history of psoriasis, rheumatoid arthritis or ankylosing spondylitis were enrolled in the study as a control group. The following morbidities were analyzed: hypo- and hyperthyroidism, hypo- and hyperparathyroidism, hyperprolactinemia, Cushing’s disease, Addison’s disease, diabetes insipidus, diabetes mellitus (DM), pituitary adenoma, acromegaly and osteoporosis. A t-test was used to compare continuous variables and a chi-square test was used for categorical variables. A univariable model and multivariable logistic regression models were used to assess the association between PsA and endocrine co-morbidities.

Results:

The study included 3161 patients with PsA, 1474 males (46.6%) and 1687 (53.4%) females, with a mean age of 58.36 ±15.42 years, and 31610 controls. Comparative analyses demonstrated higher prevalence of hypothyroidism (12.7% vs. 8.6% p<0.0001), Cushing's disease (0.3% vs. 0.1% p<0.0001), osteoporosis (13.2% vs. 9.1% p <0.001) and DM (27.9% vs. 20.7% p <0.0001) in the PsA population compared to the control group, respectively. The prevalence of hyperthyroidism, hypo- and hyperparathyroidism, hyperprolactinemia, Addison's disease, diabetes insipidus, pituitary adenoma and acromegaly was not statistically different between the two groups. In multivariate regression analysis models, hypothyroidism after adjustment for age and gender (OR 1.61 95%CI 1.43-1.80), DM after adjustment for age, gender, smoking, obesity and  steroids use (OR 1.30 95% CI 1.18-1.42), Cushing's disease after adjustment for age, gender and steroids use (OR=3.79 95% CI 1.64-8.77) and osteoporosis after adjustment for age, gender, steroids use and smoking (OR=1.50 95% CI 1.33-1.70) had a higher prevalence in PsA patients.

Conclusion:

A high prevalence of hypothyroidism, osteoporosis, DM and Cushing’s disease was found in this cohort of PsA patients. It is recommended that medical practitioners be aware of and look for these co-morbidities while taking care of PsA patients.

Disclosure:

D. Zisman,
None;

R. I. Ashkenazi,
None;

H. Bitterman,
None;

G. Shallom,
None;

I. Feldhamer,
None;

I. Lavi,
None;

S. Greenberg-Dotan,
None;

A. D. Cohen,
None.

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/endocrine-co-morbidities-in-patients-with-psoriatic-arthritis-a-population-based-study/