ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2489

Differences in Clinical Characteristics, Quality of Life, Disability, and Work Productivity in Psoriatic Arthritis Patients by Gender: Findings from a Cross-sectional Survey in the US and Europe

Laure Gossec1, Jessica Walsh 2, Kaleb Michaud 3, Steve Peterson 4, Elizabeth Holdsworth 5, Chetan Karyekar 4, Nicola Booth 6, Jessalyn Kemp 7, Soumya Chakravarty 8, Shelly Kafka 9 and Alexis Ogdie 10, 1Sorbonne Université and Hôpital Pitié-Salpêtrière, Paris, France, 2Division of Rheumatology, University of Utah, Salt Lake City, UT, 3University of Nebraska Medical Center, Omaha, NE, 4Janssen Global Services, LLC, Horsham, PA, 5Adelphi Real World, Manchester, England, United Kingdom, 6Adelphi Real World, Bollington, United Kingdom, 7Adelphi Real World, Manchester, United Kingdom, 8Janssen Scientific Affairs, LLC; Drexel University College of Medicine, Horsham; Philadelphia, PA, 9Janssen Scientific Affairs, LLC, Horsham, PA, 10Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Meeting: 2019 ACR/ARP Annual Meeting

Keywords:

Session Information

Date: Tuesday, November 12, 2019

Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster III: Psoriatic Arthritis, Clinical Features

Session Type: Poster Session (Tuesday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Psoriatic arthritis (PsA) prevalence is equal in men and women, though gender may play a role in driving mechanisms of PsA leading to differences in manifestations of clinical disease (1). This analysis assessed key differences in clinical characteristics, disability, quality of life, and work productivity by gender in real-world practice.

Methods: Cross-sectional survey of rheumatologists and dermatologists and their patients in France, Germany, Italy, Spain, UK, and US. Data were collected from Jun-Aug 2018 via physician-completed patient record forms and patient self-completed forms. Data were analyzed by gender. Demographic characteristics, treatment use, and clinical characteristics (Tender Joint Count [TJC], Swollen Joint Count [SJC], Body Surface Area [BSA] psoriasis) were reported by physicians, while quality of life (EQ5D and PsAID12), disability (HAQ-DI), and work productivity (WPAI) were reported by patients. Men and women were compared using parametric tests and non-parametric tests where appropriate.

Results: Data were collected for 2270 patients (595 US, 1675 Europe). Demographic characteristics, time from first symptoms to diagnosis, biologic treatment, and clinical characteristics were comparable between women and men (Table 1). More women reported worse quality of life, disability, and work activity impairment than men (Table 2).

Conclusion: Conclusion: In women and men with similar PsA disease activity and treatment rates, women experienced worse quality of life, greater disability, and greater work impairment, despite a lower burden of comorbidities.

References:

  1. Billi AC, Kahlenberg JM, Gudjonsson JE. Sex bias in autoimmunity. Curr Opin Rheumatol. 2019 Jan;31(1):53–61.

Table 1

Table 2

Disclosure: L. Gossec, Abbvie, 5, AbbVie, 5, Abbvie, Biogen, BMS, Celgene, Lilly, Novartis, Pfizer, SAnofi-Aventis, UCB, 5, Amgen, 5, Biogen, 5, BMS, 2, 5, Celgene, 5, Celgene Corporation, 2, Janssen, 5, Lilly, 2, 5, MSD, 5, Nordic Pharma, 5, Novartis, 5, Pfizer, 2, 5, Sanofi, 5, Sanofi-Aventis, 5, UCB, 5; J. Walsh, AbbVie, 2, 5, ABBVIE, NOVARTIS, LILLY, AMGEN, UCB, 5, Amgen, 2, 5, Janssen Research & Development, LLC, 2, Lilly, 2, 5, Novartis, 2, 5, Pfizer, 2, 5, PFIZER, ABBVIE, 2, UCB, 5; K. Michaud, FORWARD, The National Databank for Rheumatic Diseases, 3, Pfizer, 2, Pfizer & Rheumatology Research Foundation, 2, Rheumatology Research Foundation, 2, University of Nebraska Medical Center, 3; S. Peterson, Janssen, 1, 3, BMS, 3; E. Holdsworth, None; C. Karyekar, Abbott, 3, BMS, 3, Janssen, 1, 3, Janssen Scientific Affairs, LLC, 3, Novartis, 3; N. Booth, Adelphi Real World, 3; J. Kemp, None; S. Chakravarty, Janssen Research & Development, LLC, 3, Janssen Scientific Affairs, LLC, 1, 3, Johnson & Johnson, 1, 3; S. Kafka, Janssen Research & Development, LLC, 3, Janssen Scientific Affairs, LLC, 1, 3; A. Ogdie, Novartis, 5, 9, Pfizer, 5, 9, Abbvie, 5, Amgen, 5, BMS, 5, Celgene, 5, Corrona, 5, Lilly, 5, Takeda, 5.

To cite this abstract in AMA style:

Gossec L, Walsh J, Michaud K, Peterson S, Holdsworth E, Karyekar C, Booth N, Kemp J, Chakravarty S, Kafka S, Ogdie A. Differences in Clinical Characteristics, Quality of Life, Disability, and Work Productivity in Psoriatic Arthritis Patients by Gender: Findings from a Cross-sectional Survey in the US and Europe [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/differences-in-clinical-characteristics-quality-of-life-disability-and-work-productivity-in-psoriatic-arthritis-patients-by-gender-findings-from-a-cross-sectional-survey-in-the-us-and-europe/. Accessed .

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