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Abstract Number: 1967

Deregulation of Interleukin-22 Pathway in Giant Cell Arteritis

Stefania Croci1, Alessandro Zerbini1, Francesco Muratore2, Lucia Belloni3, Francesco Ciccia4, Luigi Boiardi2, Elena Simonazzi3, Alberto Cavazza5, Luca Cimino6, Antonio Moramarco6, Aroldo Rizzo7, Maria Parmeggiani8 and Carlo Salvarani9,10, 1Clinical Immunology, Allergy and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 2Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 3Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 4Rheumatology Unit, University of Palermo, Palermo, Italy, 5Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 6Ophthalmology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 7Pathology Unit, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy, 8. Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 9Rheumatology, Arcispedale S.Maria Nuova, Reggio Emilia, Italy, 10Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Giant cell arteritis and interleukins (IL)

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Session Information

Date: Monday, November 9, 2015

Title: Vasculitis Poster II

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Interleukin-22 (IL-22) is produced by immune cells but acts only on non-hematopoietic cells, particularly at the barrier interface. We thus hypothesized that IL-22 pathway might be deregulated in giant cell arteritis (GCA), an inflammatory vasculitis affecting large and medium-sized arteries.

Methods: 22 patients subjected to temporal artery biopsy (TAB) at the Arcispedale Santa Maria Nuova-IRCCS (Reggio Emilia, Italy) for a suspicion of GCA were included in the study. They were divided in two groups after histological analysis: GCA patients with TABs showing a transmural immune infiltrate (n=15) and patients with non-inflamed TABs who received a different diagnosis (n=7). Healthy subjects were also included for the analyzes in peripheral blood (n=10). Expression of IL-22 and IL-22 receptor chain 1 (IL-22R1) were determined in TABs by immunohistochemistry. Levels of IL-22 in peripheral blood mononuclear cells (PBMCs) were investigated by real-time PCR and in plasma by ELISA.

Results: IL-22 and IL-22R1 were more expressed in inflamed TABs compared to normal TABs. IL-22 was mainly expressed by granulomas and cells of the media layer. IL-22R1 was mainly expressed by endothelial cells facing the arterial lumen. Expression of IL-22 mRNA was higher in PBMCs from GCA patients compared to healthy subjects. Similarly, GCA patients had an higher concentration of IL-22 in plasma. Levels of IL-22 in plasma positively correlated with IL-22 gene expression in PBMCs and with serum C-reactive protein. Ongoing studies with flow cytometry will allow to determine if Th22 lymphocytes are also deregulated in GCA patients.

Conclusion: Increased production of IL-22 might be involved in GCA pathogenesis.


Disclosure: S. Croci, None; A. Zerbini, None; F. Muratore, None; L. Belloni, None; F. Ciccia, None; L. Boiardi, None; E. Simonazzi, None; A. Cavazza, None; L. Cimino, None; A. Moramarco, None; A. Rizzo, None; M. Parmeggiani, None; C. Salvarani, None.

To cite this abstract in AMA style:

Croci S, Zerbini A, Muratore F, Belloni L, Ciccia F, Boiardi L, Simonazzi E, Cavazza A, Cimino L, Moramarco A, Rizzo A, Parmeggiani M, Salvarani C. Deregulation of Interleukin-22 Pathway in Giant Cell Arteritis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/deregulation-of-interleukin-22-pathway-in-giant-cell-arteritis/. Accessed .
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