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Abstract Number: 1939

Definitions and Reliability Assessment of Chronic Ultrasound Lesions of the Axillary Artery in Giant Cell Arteritis: A Study from the OMERACT Large Vessel Vasculitis Ultrasound Working Group

Valentin Schaefer1, Stavros Chrysidis2, Greta Carrara3, Wolfgang Schmidt4, George A. Bruyn5, Bhaskar Dasgupta6, Eugenio De Miguel7, Andreas Diamantopoulos8, Christina Duftner9, Ulrich Fredberg10, Berit Nielsen11, Wolfgang Hartung12, Alojzija Hocevar13, Annamaria Iagnocco14, Aaron Juche4, Tanaz Kermani15, Tove Lorenzen16, Pierluigi Macchioni17, Marcin Milchert18, Uffe Døhn19, Sara Monti20, Chetan Mukhtyar21, Cristina Ponte22, Carlo Scire23, Lene Terslev24, Luca Seitz25 and Christian Dejaco26, 1Clinic of Internal Medicine III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, 2Sydvestjysk Sygehus Esbjerg, Esbjerg, Denmark, 3Epidemiology Unit, Italian Society for Rheumatology, Milan, Italy, 4Immanuel Krankenhaus Berlin Buch, Berlin, Germany, 5Rheumatology, Reumakliniek Lelystad, Lelystad, Netherlands, 6Rheumatology, Mid and South Essex University Hospital NHS Foundation Trust, Southend University Hospital, United Kingdom, Westcliff on sea, England, United Kingdom, 7Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, 8Martina Hansens Hospital, Baerum, Norway, 9Medical University Innsbruck, Innsbruck, Austria, 10Silkeborg Regional Hospital, Silkeborg, Denmark, 11Aarhus University Hospital, Aarhus, Denmark, 12Asklepios Klinik Bad Abbach, Bad Abbacg, Germany, 13University Medical Center, Rheumatology, Ljubljana, LJUBLJANA, Slovenia, 14Università degli Studi di Torino, Academic Rheumatology Centre, Turin, Italy, 15David Geffen School of Medicine / University of California, Los Angeles, CA, 16Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 17Unità Operativa di Reumatologia/Arcispedale S. Maria Nuova, Reggio Emilia, Italy, 18Pomeranian Medical University, Szczecin, Poland, 19Center for Rheumatology and Spine Diseasesand COPECARE, Copenhagen, Denmark, 20Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy, 21Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom, 22Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal, 23University of Ferrara, Ferrara, Italy, 24Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup., Copenhagen, Denmark, 25Department of Rheumatology, Immunology and Allergology, University of Bern, Inselspital, Switzerland, Bern, Switzerland, 26South Tyrol Health Trust, Hospital of Bruneck, Bruneck, Italy

Meeting: ACR Convergence 2020

Keywords: Diagnostic criteria, giant cell arteritis, OMERACT, Ultrasound, Vasculitis

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Session Information

Date: Monday, November 9, 2020

Title: Vasculitis – Non-ANCA-Associated & Related Disorders Poster II

Session Type: Poster Session D

Session Time: 9:00AM-11:00AM

Background/Purpose: The OMERACT Ultrasound (US) large vessel vasculitis task force has recently defined the US appearance of normal axillary arteries (AA) and the key elementary US lesions in acute giant cell arteritis (GCA) of the AA (i.e.:“non-compressible halo sign”). The aim of the present study was to assess the reliability of a new OMERACT definition for the US appearance of chronic GCA lesions of the AA in a web-based reliability exercise (Table 1)

Methods: The reliability exercise was performed using a REDCap. One-hundred-fifty anonymized still images from AA, were assessed (50 each from chronic and acute GCA, and 50 from healthy individuals). Chronic GCA patients had a disease duration of more than one year and were in remission. Acute GCA patients had new-onset disease with glucocorticoid treatment duration ≤1 week.  The members of the OMERACT Large Vessel Vasculitis Ultrasound Working Group (n=23, all ultrasound experts in GCA) were asked to assign all images to the categories of normal, acute GCA or chronic GCA applying the definitions agreed in previous Delphi exercises. In order to assess the intra-observer reliability, all task force members were asked to repeat the reliability exercise in a time range of at least two weeks later and using the same images presented in a different order. Light’s κ were used for evaluating intra- and inter-reader reliability, respectively. Κ values of 0–0.2 were considered slight, 0.2–0.4 fair, 0.4–0.6 moderate, 0.6–0.8 substantial and 0.8–1 excellent.

Results: The response rate for both rounds was 100%. The reliability of the new OMERACT definition for the US appearance of chronic GCA of the AA was substantial to excellent with Light’s kappa values of 0.79-0.80 for inter-reader reliability and mean Cohen-kappa values of 0.88. The mean inter-rater agreements were 86-87%. The mean intra-reader agreements were 92% (Table 2).

Conclusion: Inter- and intra-observer agreement on the evaluation of US still images from normal, acute and chronic GCA AA was substantial to excellent when applying the new OMERACT definitions for key elementary US lesions in GCA of the AA. Further exercises are planned in order to test the reliability in patients with chronic GCA US changes of the AA.


Disclosure: V. Schaefer, None; S. Chrysidis, None; G. Carrara, None; W. Schmidt, None; G. Bruyn, None; B. Dasgupta, Roche Chugai, 2, 5, 8, Sanofi, 2, 5, Abbvie, 2; E. De Miguel, AbbVie, 2, 5, 8, BMS, 8, MSD, 8, Novartis, 2, 5, 8, Pfizer, 2, 5, 8, Roche, 8, UCB, 8; A. Diamantopoulos, Sanofi, 5, Roche, 8; C. Duftner, None; U. Fredberg, None; B. Nielsen, Roche, 8, Sanofi, 5; W. Hartung, Abbvie, 8, Celgen, 8, Chugai, 8; A. Hocevar, None; A. Iagnocco, None; A. Juche, None; T. Kermani, None; T. Lorenzen, None; P. Macchioni, None; M. Milchert, None; U. Døhn, None; S. Monti, None; C. Mukhtyar, None; C. Ponte, None; C. Scire, None; L. Terslev, AbbVie, 8, MSD, 8, Novartis, 8, Roche, 8, Pfizer, 8, General Electric (GE), 8, Bristol Myers Squibb (BMS), 8, Janssen, 8; L. Seitz, None; C. Dejaco, Roche, 8, Janssen, 5, 8, Celgene, 2, Sanofi, 5, 8, AbbVie, 5, 8, BMS, 8, Pfizer, 8, Novartis, 8, Lilly, 8.

To cite this abstract in AMA style:

Schaefer V, Chrysidis S, Carrara G, Schmidt W, Bruyn G, Dasgupta B, De Miguel E, Diamantopoulos A, Duftner C, Fredberg U, Nielsen B, Hartung W, Hocevar A, Iagnocco A, Juche A, Kermani T, Lorenzen T, Macchioni P, Milchert M, Døhn U, Monti S, Mukhtyar C, Ponte C, Scire C, Terslev L, Seitz L, Dejaco C. Definitions and Reliability Assessment of Chronic Ultrasound Lesions of the Axillary Artery in Giant Cell Arteritis: A Study from the OMERACT Large Vessel Vasculitis Ultrasound Working Group [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/definitions-and-reliability-assessment-of-chronic-ultrasound-lesions-of-the-axillary-artery-in-giant-cell-arteritis-a-study-from-the-omeract-large-vessel-vasculitis-ultrasound-working-group/. Accessed .
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