ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 513

Cumulative Association of Genetic Variants with Rheumatoid Joint Damage Progression in Mexican Americans and European Americans

Rector Arya1, Inmaculada del Rincon2, Jose Felix Restrepo3, Vidya S Farook4, Christopher P Jenkinson5, Ravindranath Duggirala6 and Agustin Escalante7, 1Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 3Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 4Genetics, Texas Biomedical Research Institute, San Antonio, TX, 5University of Texas Health Science Center at San Antonio, San Antonio, TX, 6Regional Academic Health Center, Harlingen, TX, 7Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: genetics, joint damage, longitudinal studies and rheumatoid arthritis (RA)

  • Tweet
  • Email
  • Print
Session Information

Date: Sunday, November 8, 2015

Title: Rheumatoid Arthritis - Clinical Aspects Poster I

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

Genealogical and genetic
association studies have suggested that joint damage in rheumatoid arthritis (RA)
may be heritable. We and others have found a number of specific genetic
variants associated the extent of rheumatoid joint damage. Here, we estimate
the cumulative association of single nucleotide polymorphisms (SNPs) associated
with joint damage in a cohort of Mexican Americans (MA) and European Americans
(EA) with RA.

 

Methods:

We recruited MA and EA
patients with RA from rheumatology practices, and followed them over time. We used
the Immunochip array to identify single nucleotide polymorphisms associated
with the extent of radiographic joint damage on the latest available
radiograph, quantified by inverse normal Sharp scores. Association analyses
were conducted using PLINK, adjusting for age at RA onset, sex, RA duration and
the first two ethnic principal components to adjust for population
stratification. Association analyses were stratified by ethnic group. We
excluded SNPs with call rates below 95% or minor allele frequencies below 1%, and
patients with admixture or cryptic kinship relationships. We used the six SNPs
with the strongest association with joint damage in each ethnic group as
defined by a P-value ≤ 10-5, to construct a cumulative scale by summing
the number of damage-associated alleles in each patient. We examined the
association of the cumulative SNP scale with joint damage progression over the
duration of the study using scale x RA duration product terms in generalized
estimating equations adjusted for age at RA onset, sex and ethnic group.

 

Results:

Genotypic and joint
damage data were available for 675 MAs and 410 EAs. These patients had 3,186
Sharp scores available, covering a period of 4,149 patient-years (mean 3.8
years per patient, range 0 to 19). The Sharp score increased by 4.1 per year of
disease (95% C.I. 3.98, 4.35), without difference between ethnic groups. The
mean number of damage-associated SNPs in each patient was 4.4 (range 0 to 12),
each additional SNP associated with an increase Sharp progression rate of 0.2 per
year (95% CI 0.1, 0.3; P ≤ 0.001).  Among patients with 3 or less risk
alleles, Sharp increased by 3.6 per year (3.4, 3.9); among patients with 4 to 6
alleles, Sharp increased by 4.1 per year (3.9, 4.3), and among patients with 7
or more alleles, Sharp increased by 4.9 per year (4.5, 5.3). The figure plots
Sharp score over disease duration, according to the number of damage associated
SNPs.

 

Conclusion:

Genetic variants
associated with joint damage display a cumulative association, patients with a
greater number of SNPs displaying greater joint damage. These findings may
provide insights into the biology of joint damage in RA and if validated in
other populations, could be of use for the early identification of RA patients
at risk for joint damage.

 


Disclosure: R. Arya, None; I. del Rincon, None; J. F. Restrepo, None; V. S. Farook, None; C. P. Jenkinson, None; R. Duggirala, None; A. Escalante, None.

To cite this abstract in AMA style:

Arya R, del Rincon I, Restrepo JF, Farook VS, Jenkinson CP, Duggirala R, Escalante A. Cumulative Association of Genetic Variants with Rheumatoid Joint Damage Progression in Mexican Americans and European Americans [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/cumulative-association-of-genetic-variants-with-rheumatoid-joint-damage-progression-in-mexican-americans-and-european-americans/. Accessed .
  • Tweet
  • Email
  • Print

« Back to 2015 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/cumulative-association-of-genetic-variants-with-rheumatoid-joint-damage-progression-in-mexican-americans-and-european-americans/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology