Session Information
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: Correct assessment to biologics in rheumatoid arthritis (RA) patients is extremely important regarding future patient management. There is still an open debate about the utility of joint ultrasound (US) parameters and the monitoring of the activity.
Methods:
52 consecutive RA patients on stable RTX treatment administered each 6 months were evaluated. Clinical and US evaluation were performed by two independent assessors, the same day as all laboratory tests. The scanning technique and the settings of the machine (ESAOTE MY LAB70, 15MHz linear probe) were the same for all patients. Examinations were performed by a trained ultrasonographer blinded to all clinical evaluations. US of both hands (dorsal wrist, 2nd to 5th volar metacarpophalangeal and 2nd to 4th volar proximal interphalangeal) was done. All patients were separated in 2 groups according to calculated SDAI, patients having SDAI <3.3 being included in remission group and those with higher SDAI in active disease group.
Results:
86.5% were females, mean age 57.21(11.35) years, mean disease duration 14.12(7.68) years, 82.7% had a csDMARD associated to RTX . Mean DAS28 ESR was 3.12(1.27) and mean SDAI was 7.83(7.75). No significant correlations were found between active synovitis score and VAS (r=0.189, P=0.179), PGA (r=0.251, P=0.073), ESR (r=0.154, P=0.275), nor CRP (r=0.173, P=0.220). Active synovitis score correlated to tender joint count (r=0.368, P=0.007), swollen joint count (r=0.413, P=0.002), SDAI score (r=0.339, P=0.014) and DAS28 score (r=0.348, P=0.011). Boolean remission correlated inversely to number of PD joints (r=-0.416, P=0.002), active sinovitis (r=-0.492, P<0.001). There were significant differences between patients with active disease and RA remission based on SDAI score regarding tender joint count, swollen joint count, ESR, PD joint count, total PD score and active synovitis (see table). SDAI remission correlated inversely to PD joint number (r=-0.383, P=0.005), active synovitis (r=-0.385, P=0.005) and total PD score (r=-0.456, P=0.001). SDAI remission did not correlate to GS joint number (r=-0.039, P=0.785) nor to total GS score (r=-0.140, P=0.324).
|
|
SDAI Remission (SD) |
SDAI Active Disease (SD) |
P |
|
DMARD use |
0.85(0.37) |
0.82(0.38) |
|
|
Tender joint count |
0.08(0.277) |
2.67(3.79) |
0.018 |
|
Swollen joint count |
0.00(0.00) |
1.95(2.74) |
0.014 |
|
CRP |
4.43(5.59) |
11.55(17.81) |
0.165 |
|
ESR |
9.15(4.70) |
23.41(17.93) |
0.007 |
|
RF |
21.57(30.69) |
34.01(48.62) |
0.409 |
|
ACPA |
249.41(611.87) |
407.92(672.44) |
0.471 |
|
GS joint number |
6.23(3.94) |
5.95(2.72) |
0.776 |
|
PD joint number |
1.08(1.75) |
2.33(1.51) |
0.016 |
|
Total GS score |
8.62(5.37) |
10.00(5.29) |
0.420 |
|
Total PD score |
1.08(1.75) |
3.23(2.28) |
0.003 |
|
Active synovitis |
0.46(0.51) |
0.85(0.36) |
0.005 |
Conclusion: Total PD score and PR joint numebr, but not GS score or GS joint number, correlates with SDAI remission in RA patients treated with RTX.
To cite this abstract in AMA style:
Borangiu A, Mazilu D, Saulescu I, Iachim E, Grosanu L, Constantinescu C, Balanescu A, Predeteanu D, Ionescu R, Opris D. Correlations Between Clinical, Laboratory and Ultrasound Joint Examination in RA Patients Treated with Rituximab [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/correlations-between-clinical-laboratory-and-ultrasound-joint-examination-in-ra-patients-treated-with-rituximab/. Accessed .« Back to 2015 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/correlations-between-clinical-laboratory-and-ultrasound-joint-examination-in-ra-patients-treated-with-rituximab/