Correlation Between the Lupus Foundation of America - Rapid Evaluation of Activity in Lupus (LFA-REAL) Patient Reported Outcome (PRO) and Health-Related Quality of Life (HRQoL) and Other PROs in a Primarily Mestizo Population

Manuel Ugarte-Gil¹, Rocío-V. Gamboa-Cárdenas ², Victor Pimentel-Quiroz ³, Cristina Reátegui-Sokolova ⁴, Paola Zeña-Huancas ², Mariela Medina ², Claudia Elera-Fitzcarrald ¹, Luciana Gil ², Samira García ⁴, Francisco Zevallos ⁴, Cesar Pastor-Asurza ⁴, Zoila Rodríguez-Bellido ², Anca Askanase ⁵, Joan Merrill ⁶, Graciela Alarcón ⁷ and Risto Perich-Campos ², ¹Universidad Científica del Sur, Lima, Peru, ²Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Lima, Peru, ³Hospital Nacional Guillermo Almenara Irigoyen - EsSalud, Lima, Lima, Peru, ⁴Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ⁵Columbia University, New York, ⁶Oklahoma Medical Research Foundation, Oklahoma City, ⁷University of Alabama at Birmingham, Birmingham

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: Disease Activity and quality of life, Systemic lupus erythematosus (SLE)

Session Information

Date: Sunday, November 10, 2019

Title: SLE – Clinical Poster I: Epidemiology & Pathogenesis

Session Type: Poster Session (Sunday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Disease activity in systemic lupus erythematosus (SLE) is understood differently by patients and physicians; furthermore, there are no reliable measures for patients to assess their levels of disease activity. The LFA-REAL PRO has been proposed for addressing this void, and it is expected to correlate with HRQoL and with other PROs. The aim of this study was to determine the correlations between LFA-REAL PRO and HRQoL, fatigue and work disability.

Methods: A cross-sectional analyses of patients from a single-center cohort was performed. The disease activity measure included was the LFA-REAL PRO (0-1200); PROs included were LupusQoL (with its eight domains), SF-36 (with its eight domains and two main subcomponents), FACIT (as a measure of fatigue) and WPAI (as a measure of work productivity impairment). For the LFA-REAL PRO and WPAI, the higher the scores, the worse the disease activity and the more impaired the patient is; for the SF-36, LupusQoL and FACIT is the opposite. The correlation between these indices was evaluated with Pearson correlations.

Results: One-hundred and sixty-nine patients with SLE, with a mean age of 45.8 (SD: 14.2), 156 (92.3%) were female. The mean (SD) the LFA-REAL PRO was 239.6 (187.7), the Physical Component Summary SF-36 was 53.7 (22.1) and the Mental Component Summary SF-36 was 54.6 (21.0). The mean value of the components of the LupusQoL ranged between 41.0 and 69.4. The FACIT was 33.2 (10.5), the percentage of overall work productivity impairment was 30.8 (28.1) and of activity impairment was 36.1 (29.9). LFA-REAL PRO correlated with all domains of LupusQoL, SF-36, FACIT and WPAI, with the exception of absenteeism.

Conclusion: The LFA-REAL PRO correlates with several measures of HRQoL and other outcomes relevant to lupus patients like fatigue and work disability, suggesting that this index could be useful in monitoring them.

Table 1 pro

Disclosure: M. Ugarte-Gil, None; R. Gamboa-Cárdenas, None; V. Pimentel-Quiroz, None; C. Reátegui-Sokolova, None; P. Zeña-Huancas, None; M. Medina, None; C. Elera-Fitzcarrald, None; L. Gil, None; S. García, None; F. Zevallos, None; C. Pastor-Asurza, None; Z. Rodríguez-Bellido, None; A. Askanase, Xencor, 2; J. Merrill, Xencor, 2; G. Alarcón, None; R. Perich-Campos, None.

To cite this abstract in AMA style:

Ugarte-Gil M, Gamboa-Cárdenas R, Pimentel-Quiroz V, Reátegui-Sokolova C, Zeña-Huancas P, Medina M, Elera-Fitzcarrald C, Gil L, García S, Zevallos F, Pastor-Asurza C, Rodríguez-Bellido Z, Askanase A, Merrill J, Alarcón G, Perich-Campos R. Correlation Between the Lupus Foundation of America – Rapid Evaluation of Activity in Lupus (LFA-REAL) Patient Reported Outcome (PRO) and Health-Related Quality of Life (HRQoL) and Other PROs in a Primarily Mestizo Population [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/correlation-between-the-lupus-foundation-of-america-rapid-evaluation-of-activity-in-lupus-lfa-real-patient-reported-outcome-pro-and-health-related-quality-of-life-hrqol-and-other-pros-in-a-pri/. Accessed .

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