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Abstract Number: 785

Correlation between Nailfold Capillary Number and Blood Perfusion in Systemic Lupus Erythematosus Patients

Alberto Sulli1, Barbara Ruaro1, Carmen Pizzorni1, Vanessa Smith2, Sabrina Paolino3, Veronica Tomatis1, Monica Pendolino1 and Maurizio Cutolo1, 1Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, 2Department of Internal Medicine, Department of Rheumatology, Ghent University Hospital, Department of Internal Medicine, Ghent University, Ghent, Belgium, Ghent, Belgium, 3Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genova, Italy

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Capillaroscopy and systemic lupus erythematosus (SLE)

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Session Information

Date: Sunday, October 21, 2018

Title: Systemic Lupus Erythematosus – Clinical Poster I: Clinical Manifestations and Comorbidity

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Numerous articles have investigated peripheral microcirculation in primary Raynaud’s phenomenon (RP) (1,2). Reports evaluating peripheral microcirculation in systemic lupus erythematosus (SLE) are scanty, but the interest is increasing (3). The aim of this study was to investigate possible correlations between morphological and functional aspects of microcirculation in different skin areas of the hands and face in SLE patients and to compare the results with primary RP (PRP) patients and healthy subjects (HS).

Methods: 14 SLE patients without RP (ACR criteria) (4) (mean age 53±14 SD years, mean disease duration 7±4 years), 14 PRP patients (LeRoy criteria) (5) (mean age 53±17 years, mean RP duration 6±5 years) and 14 HS (mean age 50±17 years) were enrolled during the winter period, after informed consent. Nailfold videocapillaroscopy (NVC) and laser speckle contrast analysis (LASCA) were performed in the three groups of patients. The absolute nailfold capillary number (CN) per linear millimeter at first distal row was assessed by NVC. Blood perfusion (BP) was detected by LASCA at the level of fingertips, periungual areas, dorsum and palm of both hands and face. The average BP was calculated as perfusion units (PU) (2). Patients were not taking vasodilator drugs since at least one month before study entry. Statistical analysis was performed by non parametric tests.

Results: SLE patients showed a positive correlation between nailfold CN and BP in all areas of hands (p<0.0001), but no statistically significant correlation was observed between nailfold CN and BP at the level of face (p=0.10). In both PRP and HS no statistically significant correlation was observed between nailfold CN and BP in all examined areas (p=0.70 and p=0.20, respectively). SLE patients showed a statistically significant lower nailfold CN than both PRP and HS (median 9.1 vs 10.3 vs 11.0, respectively, p<0.0005). Conversely, no statistically significant difference of nailfold CN was observed between PRP and HS. PRP patients showed a statistically significant lower BP than both SLE and HS at the level of fingertip (median 90, 114, 187 PU, respectively; p<0.0001), periungual (median 74, 100, 141 PU, respectively, p<0.0001), dorsal (median 61, 72, 128 PU, respectively, p<0.0001), and palm areas (median 76, 96, 124 PU, respectively, p<0.0001). Conversely, PRP, SLE and HS patients showed similar BP values at the level of face (median 141, 139, 137 PU, respectively, p=0.30).

Conclusion: This study demonstrates a correlation between morphological and functional microvascular features in SLE patients. SLE patients without RP have a subclinical microangiopathy, showing lower nailfold CN and BP than HS. Conversely, PRP patients show only a functional dysfunction, having a lower peripheral skin BP than both SLE patients and HS. The clinical value of this finding is undergoing further analysis, and open the door to new clinical insight.

References. 1.Cutolo M, et al. J Rheumatol 2010;37:1174-80. 2.Ruaro B, et al. Ann Rheum Dis 2014;73:1181-5. 3.Cutolo M, et al. Autoimmun Rev. 2018;17:344-352. 4.Petri M et al. Arthritis Rheum. 2012;64:2677-86. 5.LeRoy EC, et al. Clin Ex Rheumatol.1992;10:485-8.


Disclosure: A. Sulli, None; B. Ruaro, None; C. Pizzorni, None; V. Smith, None; S. Paolino, None; V. Tomatis, None; M. Pendolino, None; M. Cutolo, None.

To cite this abstract in AMA style:

Sulli A, Ruaro B, Pizzorni C, Smith V, Paolino S, Tomatis V, Pendolino M, Cutolo M. Correlation between Nailfold Capillary Number and Blood Perfusion in Systemic Lupus Erythematosus Patients [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/correlation-between-nailfold-capillary-number-and-blood-perfusion-in-systemic-lupus-erythematosus-patients/. Accessed .
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