Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: It is well known that the use of corticosteroids results in increased viral replication and elevated ALT in patients with hepatitis B virus. The use of high dose corticosteroids for more than 4 weeks usually results in hepatitis worsening after cessation of steroids. However, few studies have investigated the effect of low dose corticosteroids on hepatitis B virus (HBV) reactivation. The aim of this study is to investigate the reactivity of HBV in rheumatoid arthritis patients treated with long-term low dose corticosteroids.
Methods: Patients with HBsAg positive who were diagnosed with rheumatoid arthritis and who received prednisolone of less than 10 mg/day over four weeks were selected at four university hospitals. Medical records and laboratory data were retrospectively analyzed and multivariate analysis was performed.
Results: One hundred
Conclusion: The hepatitis B virus can be exacerbated by spontaneous viral reactivation, so it is difficult to conclude that hepatitis is caused by the administration of steroids. In this study, the administration of low-dose steroids did not affect the reactivation of HBV, suggesting that it could be used safely. Further, prospective studies on the effect of conventional disease-modifying antirheumatic drugs such as leflunomide and hydroxychloroquine on the reactivation are needed.
To cite this abstract in AMA style:Jeong W, Kim J, Ghang B, Song BC. Correlation between Long-Term Low-Dose Steroid Administration and Reactivation of Hepatitis B Virus in Patients with Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/correlation-between-long-term-low-dose-steroid-administration-and-reactivation-of-hepatitis-b-virus-in-patients-with-rheumatoid-arthritis/. Accessed September 26, 2020.
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