Comparison of M-DAS and DAS28, Two Composite Scores for Prediction of Structural Damages in Rheumatoid Arthritis: Data from the Espoir Cohort

Marion Couderc¹, Bruno Pereira², B G Combe³, Valerie Devauchelle⁴, Xavier Mariette⁵ and Martin Soubrier¹, ¹Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, ²Biostatistics unit (DRCI), CHU Clermont-Ferrand, Clermont-Ferrand, France, ³Hospital Lapeyronie, Immuno-Rheumatology, Montpellier, France, ⁴Service de Rhumatologie, CHU Brest, Brest, France, ⁵Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Disease Activity and rheumatoid arthritis (RA)

Session Information

Date: Tuesday, November 10, 2015

Title: Rheumatoid Arthritis - Clinical Aspects Poster Session III

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Numbers of composite scores are available to assess disease activity in rheumatoid arthritis (RA), the most widely used being the Disease-Activity-Score in 28 joints (DAS28), the Simplified-Disease-Activity-Index (SDAI), and the Clinical-Disease-Activity-Score (CDAI). Baker et al. have recently developed a modified version of these scores (M-DAS28, M-CDAI, M-SDAI) based on widely available clinical measures (swollen joint count [SJC] evaluator global assessment of disease activity [EvGA] and CRP level). (1) These scores demonstrated superior correlation with MRI detection of synovitis and more accurately predicted radiographic progression after 1 year than DAS28 and SDAI.The objective of the study was to evaluate the performance of new composite disease activity scores (M-DAS28, M-SDAI and M-CDAI]) compared to conventional measures (DAS28, SDAI and CDAI) to predict radiographic progression in rheumatoid arthritis patients from the ESPOIR cohort.

Methods: The French multicentric ESPOIR cohort included a total of 664 patients with early (< 6 months) unclassified arthritis. This study was conducted on the patients fulfilling the ACR/EULAR 2010 classification criteria for RA. The M-DAS28, M-SDAI, and M-CDAI were respectively compared to the DAS28, CDAI and SDAI for predicting radiographic progression (estimated after 1 year by The Sharp/van der Heidje [SHS] scoring system).

Results: A total of 590 RA patients (women 78%, age 48.8 years, symptoms duration 16 weeks, SJC 8, tender joint count 9, ESR 29 mm at the first hour, CRP level 22 mg/L, DAS28-ESR 5.2, DAS28-CRP 5.0, SDAI 30.4, CDAI 28.3) were included.

Ability to predict radiographic progression after 1 year was the same between baseline M-DAS28-ESR and DAS28-ESR (Area under the curve [AUC]: 0.53 [0.49–0.58] vs 0.53 [0.48–0.58] respectively), M-DAS28-CRP and DAS28-CRP (AUC : 0.54 [0.49–0.59] vs 0.52 [0.47–0.57] respectively), M-SDAI and SDAI (AUC : 0.52 [0.47–0.57] vs 0.51 [0.46–0.56] respectively), M-CDAI and CDAI (AUC: 0.51 [0.47–0.56] vs. 0.50 [0.45–0.55] respectively).

Conclusion: In conclusion, modified disease activity scores (M-DAS28-ESR, M-DAS28-CRP, M-CDAI and M-SDAI), based on clinical measures of disease activity, did not prove superiority to original disease activity scores on ability to predict structural progression in patients with RA.

Reference :

1 – Baker JF, Conaghan PG, Smolen JS, Aletaha D, Shults J, Emery P, et al. Development and validation of modified disease activity scores in rheumatoid arthritis: Superior correlation with MRI synovitis and X-ray progression. Arthritis Rheum. 2014;66:794-802

Disclosure: M. Couderc, None; B. Pereira, None; B. G. Combe, None; V. Devauchelle, None; X. Mariette, None; M. Soubrier, None.

To cite this abstract in AMA style:

Couderc M, Pereira B, Combe BG, Devauchelle V, Mariette X, Soubrier M. Comparison of M-DAS and DAS28, Two Composite Scores for Prediction of Structural Damages in Rheumatoid Arthritis: Data from the Espoir Cohort [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/comparison-of-m-das-and-das28-two-composite-scores-for-prediction-of-structural-damages-in-rheumatoid-arthritis-data-from-the-espoir-cohort/. Accessed .

« Back to 2015 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/comparison-of-m-das-and-das28-two-composite-scores-for-prediction-of-structural-damages-in-rheumatoid-arthritis-data-from-the-espoir-cohort/