Clinical Features and Characteristics of Juvenile Idiopathic Arthritis-Associated Uveitis in Japan：the First Report from the Pediatric Rheumatology Association of Japan (PRAJ)

Junko Yasumura¹, Masato Yashiro², Nami Okamoto³, Kosuke Shabana⁴, Hiroaki Umebayashi⁵, Naomi Iwata⁶, Tomohiro Kubota⁷, Mao Mizuta⁸, Kenichi Nishimura⁹, Yuka Okura¹⁰, Masaki Shimizu⁸, Minako Tomiita¹¹, Syuji Takei⁷ and Masaaki Mori¹², ¹Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan, ²Department of Pediatrics, Okayama University Hospital, Okayama, Japan, ³Pediatrics, Graduate School of Medicine, Osaka Medical College, Takatsuki, Japan, ⁴Department of Pediatrics, Graduate School of Medicine, Osaka Medical College, Takatsuki, Japan, ⁵Department of Rheumatics, Miyagi Children’s Hospital, Sendai, Japan, ⁶Department of Immunology and Infectious Diseases, Aichi Children’s Health and Medical Center, Obu, Japan, ⁷Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan, ⁸Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, ⁹Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ¹⁰Department of Pediatrics, KKR Sapporo Medical Center, Sapporo, Japan, ¹¹Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan, ¹²Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Juvenile idiopathic arthritis (JIA) and uveitis

Session Information

Date: Tuesday, November 7, 2017

Title: Pediatric Rheumatology – Clinical and Therapeutic Aspects Poster III: Juvenile Arthritis

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Several reports examined ethnic differences of Juvenile Idiopathic Arthritis -associated uveitis (JIA-U), however, there were no information from Japan. Therefore, PRAJ underwent multi-center surveillance in Japan to clarify the clinical and epidemiologic characteristics of JIA-U.

Methods: Questionnaires were sent to pediatric rheumatologists in Japan to investigate clinical characteristics of JIA patients.

Results: Of 726 patients involved in this study, 44 (6.1%) had JIA-U during the whole disease course. Overall 682 non-uveitis JIA patients were compared with 44 JIA-U patients. Female ratio in non-uveitis vs JIA-U was 67.6% vs 70.5%(P=0.7425). Age at JIA diagnosis was 7.3 (4.5) vs 4.9 (4.0) (mean (SD)) years old (P<0.0001). The subtype of arthritis was shown in Table. There were no patients with uveitis in poly-RF positive and systemic type. Positivity for ANA was 57.5%, for RF was 2.5% and ACPA was 0% in JIA-U patients and that of ANA was significantly higher than non-uveitis JIA patients(P<0.0001). There were no family histories of uveitis and episodes of infection before onset of uveitis. The mean age at diagnosis of uveitis was 5.5 (2.7) (mean(SD)) years old and the age under 8 years old were 82.5%. Uveitis occurred before the onset of arthritis in 5.0%, within the first 7 years after onset of arthritis in 97.5%. On the other hand, uveitis occurred during arthritis treatment in 35% and after off therapy in 20%. It occurred bilateral in 55.3% and 82.1% was anterior. 64.9% had no eye symptom, 36.8% had ocular complications (cataracts, posterior synechia of the iris, etc.), and 58% had active arthritis at the first diagnosis of uveitis. 39.5% had uveitis without arthritis at the last visit. There were no blindness, but eyes of 56.9% were not improved visual acuity at the last visit.

Conclusion: This is the first report of characteristics of JIA-U in Japan. Prevalence of JIA-U in Japan is lower than that of other country that were reported before. The reason may be because ratio of oligo-type JIA patients is lower in Japan than that of other country, though the risk factor of JIA-U of Japanese patients (oligo-type arthritis, ANA positive, early onset arthritis, RF negative) is similar that of reports from other country.

Disclosure: J. Yasumura, None; M. Yashiro, None; N. Okamoto, None; K. Shabana, None; H. Umebayashi, None; N. Iwata, None; T. Kubota, None; M. Mizuta, None; K. Nishimura, None; Y. Okura, None; M. Shimizu, None; M. Tomiita, None; S. Takei, None; M. Mori, None.

To cite this abstract in AMA style:

Yasumura J, Yashiro M, Okamoto N, Shabana K, Umebayashi H, Iwata N, Kubota T, Mizuta M, Nishimura K, Okura Y, Shimizu M, Tomiita M, Takei S, Mori M. Clinical Features and Characteristics of Juvenile Idiopathic Arthritis-Associated Uveitis in Japan：the First Report from the Pediatric Rheumatology Association of Japan (PRAJ) [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/clinical-features-and-characteristics-of-juvenile-idiopathic-arthritis-associated-uveitis-in-japan%ef%bc%9athe-first-report-from-the-pediatric-rheumatology-association-of-japan-praj/. Accessed .

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