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Abstract Number: 1467

Clinical Characteristics of Primary Sjögren’s Syndrome in Adult Patients Diagnosed at Age Less Than or Equal to 35 Years versus Those over 35 Years of Age

Noel Agustin Callahuara Goiburu1, Patricia Sasaki 1, Anastasia Secco 2, Catalan Pellet 3, Nadia Riscanevo 4, Janet Flores 5, Francisco Caeiro 5, cristina Amitrano 6, Cecilia Asnal 7, Alejandro Nitsche 8, Carolina Segura Escobar 9, Julia Demarchi 10, Damian Duartes 10, Lida santiago 11, Laura Raiti 12, Vanesa Cruzat 13, Carla Gobbi 14, Paula Alba 15, Silvia Papasidero 16, Sofia Velez 17, Vicente Juarez 18 and Gabriela Salvatierra 19, 1Rivadavia, CABA, Ciudad Autonoma de Buenos Aires, Argentina, 2Hospital Rivadavia, Caba, Buenos Aires, Argentina, 3Rivadavia, CABA, Argentina, 4Hospital Privado de Córdoba, Cordoba, Cordoba, Argentina, 5Hospital Privado de Córdoba, Cordoba, Argentina, 6Hospital Aleman, CABA, Argentina, 7Instituto Centenario, Buenos Aires, Buenos Aires, Argentina, 8Hospital Aleman, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 9Hospital Británico, Buenos Aires, Buenos Aires, Argentina, 10Hospital Británico, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 11OMI, Ciudad Autonoma de Buenos Aires, Argentina, 12Clinica Bessone, Buenos Aires, Buenos Aires, Argentina, 13Clinica Bessone, Buenos Aires, Argentina, 14CÁTEDRA DE CLÍNICA MÉDICA I, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, 15UNIDAD DE REUMATOLOGÍA, CÁTEDRA DE SEMIOLOGÍA, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, 16Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 17Consultorio Privado S.V, Buenos Aires, Buenos Aires, Argentina, 18Hospital Milagros de Salta, Salta, Salta, Argentina, 19IPRI, Santiago del estero, Santiago del Estero, Argentina

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: salivary gland and activity score, SICCA, Sjogren's syndrome, young adults

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Session Information

Date: Monday, November 11, 2019

Session Title: Sjögrenʼs Syndrome – Basic & Clinical Science Poster II

Session Type: Poster Session (Monday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Although there is little information, the debut of primary Sjögren’s syndrome in adult patients aged less than or equal to 35 years, would be expressed with less pronounced Sicca manifestations and with a high degree of systemic commitment. For this reason, we decided to compare the behavior of the disease in the Argentine population with a diagnosis of primary Sjögren’s syndrome at age less than or equal to 35 years versus those older than 35 years.

Methods: Cross-sectional observational analytical study. We analyzed the data of patients older than 18 years, with diagnosis of primary Sjögren’s syndrome (American-European criteria 2002 / ACR EULAR 2016), included in the GESSAR database (Sjögren Syndrome Study Group of the Argentine Society of Rheumatology), with minus one control in the last 12 months. The presence of systemic manifestations assessed from the domains of the ESSDAI and the glandular manifestations, and as possible confounders were considered: sex, diabetes, hypothyroidism, treatments and time of follow-up in years of each group. The continuous variables were described as mean and standard deviation or median and interquartile range (RIQ), according to distribution and sample size. The categorical variables were expressed in percentages. For the bivariate analysis, for the continuous variables, the Student or Mann Whitney test was used according to distribution and sample size. The categorical variables were analyzed using Chi square or Fisher’s exact test, according to the expected frequency distribution table. A p < 0.05 was considered statistically significant.

Results: 665 patients were included. One hundred of them with an age at diagnosis ≤ 35 years and with a mean age at diagnosis of 29 ± 4 years, 92% of them women. The average age at diagnosis of the group > 35 years was 54 ± 11 years. Within the glandular manifestations, statistically significant differences were found between ≤ 35 years vs >35 years, in xerophthalmia (90.72% vs 95.64%, p: 0.04) and xeroderma (42.35% vs 57.36%, p: 0.03). No significant differences were found in xerostomia (87.37% vs 90.33%, p: 0.38), nor xerovagina (30.86% vs 39.18%, p: 0.15). Statistically significant differences were found between ≤35 years vs >35 years in the following domains of ESSDAI: peripheral nervous system (4.05 vs 11.32, p: 0.03), respiratory (6% vs 15.40%, p: 0.01) and renal (6% vs. 1.59%, p: 0.02). In a subanalysis of ESSDAI domains, significant differences were found in arthritis (37.37% vs 27.16%, p: 0.04) and persistent dry cough (4.04% vs 11.47%, p: 0.03).

Conclusion: A significantly lower frequency of xerophthalmia and xeroderma was observed in the group ≤35 years old compared to those >35 years old. Regarding systemic activity, less involvement of the peripheral nervous system and pulmonary domain and higher in the renal domain, with statistically significant differences. These results suggest a lower glandular compromise in patients diagnosed at a younger age, without a characteristic differential pattern in terms of systemic involvement.


Table 1 General Characteristics


Table 2 results


Disclosure: N. Callahuara Goiburu, None; P. Sasaki, None; A. Secco, None; C. Pellet, None; N. Riscanevo, None; J. Flores, None; F. Caeiro, None; c. Amitrano, None; C. Asnal, None; A. Nitsche, None; C. Segura Escobar, None; J. Demarchi, None; D. Duartes, None; L. santiago, None; L. Raiti, None; V. Cruzat, None; C. Gobbi, None; P. Alba, None; S. Papasidero, None; S. Velez, None; V. Juarez, None; G. Salvatierra, None.

To cite this abstract in AMA style:

Callahuara Goiburu N, Sasaki P, Secco A, Pellet C, Riscanevo N, Flores J, Caeiro F, Amitrano c, Asnal C, Nitsche A, Segura Escobar C, Demarchi J, Duartes D, santiago L, Raiti L, Cruzat V, Gobbi C, Alba P, Papasidero S, Velez S, Juarez V, Salvatierra G. Clinical Characteristics of Primary Sjögren’s Syndrome in Adult Patients Diagnosed at Age Less Than or Equal to 35 Years versus Those over 35 Years of Age [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/clinical-characteristics-of-primary-sjogrens-syndrome-in-adult-patients-diagnosed-at-age-less-than-or-equal-to-35-years-versus-those-over-35-years-of-age/. Accessed January 27, 2021.
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