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Abstract Number: 2740

Clinical and Laboratory Characteristics of ANCA-Associated Vasculitis in Pediatric and Young Adult Patients: A Retrospective Review

Melissa Swee1, Manish Suneja2, Mandeep Gill3 and Bharat Kumar4, 1Transplant Nephrology, University of Iowa, Iowa City, IA, 2Internal Medicine, University of Iowa, Iowa City, IA, 3Division of Nephrology, University of Iowa Hospitals and Clinics, Iowa City, IA, 4Internal Medicine-Division of Immunology, University of Iowa, Iowa City, IA

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: ANCA and vasculitis

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Session Information

Date: Tuesday, October 23, 2018

Title: Vasculitis – ANCA-Associated Poster II

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: ANCA-associated vasculitis (AAV) is a heterogenous group of small-vessel vasculitides that typically affects the kidneys, respiratory tract, and other organ systems. The onset of AAV may occur at any age, although literature suggests that this is more common in older populations. We aim to characterize the clinical and laboratory manifestations of AAV based on age of onset in pediatric and adult patients younger than 35 years, compared to other age groups.

Methods: We performed a retrospective chart review of all patients with positive MPO or PR3 lab results by ELISA and a diagnosis of vasculitis from 2000 to 2017. Patients were classified into four groups according to age and divided into two groups each depending on MPO or PR3 serotypes. These features were compared to one another through descriptive statistics, as noted in the included table.

Results: 141 patients were identified based on the inclusion criteria, of which 31 were below the age of 35.  The majority of patients were white females. Upper respiratory tract involvement and arthritis were much more common in the pediatric and adults younger than 35. PR3 was also more frequent in this group as well. Renal and lower respiratory involvement were comparable between the age groups.

Conclusion: Onset of AAV in young adulthood has distinct characteristics that more closely resemble pediatric AAV than compared to their older counterparts. Prior literature demonstrates a much higher percentage of extrarenal, extra-respiratory involvement in the pediatric population, which is consistent in our sample as well. Further analysis on clinical presentation, prognosis and treatment outcomes are forthcoming.


Disclosure: M. Swee, None; M. Suneja, None; M. Gill, None; B. Kumar, None.

To cite this abstract in AMA style:

Swee M, Suneja M, Gill M, Kumar B. Clinical and Laboratory Characteristics of ANCA-Associated Vasculitis in Pediatric and Young Adult Patients: A Retrospective Review [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/clinical-and-laboratory-characteristics-of-anca-associated-vasculitis-in-pediatric-and-young-adult-patients-a-retrospective-review/. Accessed .
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