ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1113

Characterization of Lumbar Spine Individual Radiographic Features in African American and White Women and Men: The Johnston County Osteoarthritis Project

Adam P. Goode1, Amanda E. Nelson2, Kelli D. Allen3, Jordan Renner4, Timothy S. Carey5 and Joanne M. Jordan6, 1Community and Family Medicine, Duke University, Durham, NC, 2University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, 3Health Services Research, Duke and Durham VA Medical Center, Durham, NC, 4UNC School of Medicine, University of North Carolina, Chapel Hill, NC, 5UNC School of Medicine, Cecil G. Sheps Center for Health Services Research University of North Carolina, Chapel Hill, NC, 6Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC

Meeting: 2012 ACR/ARHP Annual Meeting

Keywords:

Session Information

Title: Osteoarthritis - Clinical Aspects

Session Type: Abstract Submissions (ACR)

Background/Purpose: Race and gender differences have been found to exist in hip and knee osteoarthritis (OA). Whether such differences occur with lumbar spine individual radiographic features (IRF) of disc space narrowing (DSN) and vertebral osteophytes (OST) are unknown. The purposes of these analyses are to describe differences in the severity of DSN and OST among African American and Caucasian men and women.

Methods: Lumbar spine radiographs (DSN and OST) were available for 1,633 participants returning for second follow-up in the Johnston County Osteoarthritis Project from 2008-11. Participants had a mean age 68.1 (SD 9.2), and were 68.0% female and 31.7% African American (AA), with mean body mass index (BMI) 31.4 (SD 7.2).  Seventy-eight percent had >=12 years education. Lateral lumbar spine films were graded for each level in a semi-quantitative fashion (0-3) for DSN and (0-3) for both anterior superior and inferior OST according to the Burnett Atlas. Lumbar spine IRF were coded (individually for DSN and superior and inferior OST) based upon a participant’s most severely affected lumbar level. For all analyses, AAs were the referent group and results were stratified by gender. Multivariable associations were determined with proportional odds models while adjusting for age, BMI, and education.

Results: After adjustment, White women had a significantly greater odds of DSN (adjusted Odds Ratio [aOR]= 1.56 ((95% CI 1.23, 1.98)) whereas no significant association was found across race for men (aOR= 1.24 ((95% CI 0.86, 1.79)). No association was found across race for either women (aOR=1.00 ((95% CI 0.78, 1.28)) or men (aOR= 1.13 ((95% CI 0.78, 1.65)) for superior anterior OST. White women (aOR= 1.50 ((95% CI 1.16, 1.95)) and White men (aOR= 1.88 ((95% CI 1.27, 2.77)) both had a greater odds of inferior anterior vertebral OST.

Conclusion: Severity of some lumbar spine IRFs differs by race, suggesting the possibility of anatomic or developmental variation in the spine.  The greater severity of DSN in White women compared to AA women is important because this IRF has been consistently associated with low back symptoms. The fact that both White women and White men had greater severity of inferior vertebral OST, compared with their AA counterparts, suggests anatomic racial differences in this region.

Disclosure:

A. P. Goode,
None;

A. E. Nelson,
None;

K. D. Allen,
None;

J. Renner,
None;

T. S. Carey,
None;

J. M. Jordan,

Algynomics, Inc. ,

1,

Johnson and Johnson,

5,

Johnson & Johnson,

2,

Interleukin Genetics, Inc. ,

5,

Eli Lilly and Company,

5,

Mutual Pharmaceutical Company,

5.

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