Characteristics of the Musculoskeletal Symptoms Observed Among Survivors of Ebola Virus Disease (EVD) in the Postebogui Cohort in Guinea

Yves-Marie PERS¹, Mamadou SALIOU SOW², Bernard TAVERNE³, Laura MARCH³, Jean-François ETARD³, Moumié BARRY⁴, Abdoulaye TOURE⁵ and Eric DELAPORTE³, ¹Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital Montpellier, MONTPELLIER, France, ²Infectious Disease, Donka University National Hospital, CONAKRY, Guinea, ³IRD UMI 233 INSERM U1175, University Montpellier, MONTPELLIER, France, ⁴Hôpital National Donka, CHU de Conakry, Service des Maladies Infectieuses et Tropicales, Conakry, Guinea, ⁵Department of Pharmacy, Conakry University, CONAKRY, Guinea

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: arthritis and viruses

Session Information

Date: Monday, November 14, 2016

Title: Infection-related Rheumatic Disease - Poster

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Previous studies showed that arthralgia and myalgia were the most common symptoms among Ebola virus disease (EVD) survivors. Nevertheless specific analyses of rheumatologic sequelea are still lacking.

Methods: The Postebogui study is a prospective multicenter cohort aiming to evaluate the long-term clinical, psychological and socio-behavioral outcomes of EVD survivors infected during the 2014-2015 outbreaks. Of the 216 participants included in October 22th 2015, 44 patients with arthralgia/myalgia underwent a complete examination by a rheumatologist. Data were collected using a standardized questionnaire and entered in an electronic database.

Results: 43 patients reported joint pain and one patient had myalgia only. 61% were female; median age was 31.5 years; median time from Ebola Treatment Center (ETC) discharge to rheumatologic examination was 8.8 months. Pain manifestations started after Ebola infection in all patients except one. We found similar characteristics in the whole cohort without rheumatologic examination. Morning stiffness was present in 75% of patients. Patients had mechanical pain only (45%), inflammatory pain only (9%) or both (45%). 77% had low back pain and all patients had at least one peripheral joint painful. Large joints were most frequently affected than small joints (73% vs 41%). Oligo and polyarticular presentations were similar and a symmetrical pain distribution was frequent (43-81%). Furthermore, 36 patients (82%) had at least one painful 18-tender point count, most of whom had extensive pain (n=19) and symmetric distribution (91%). Diagnoses were mainly non-specific musculoskeletal disorders (59%) and mechanical back pain (52%). No polyarthritis was observed. We found a higher percentage of depressed patients 42% versus 11% in the remaining Postebogui group (p<0.001).

Conclusion: Our study provides an in-depth analysis of rheumatic complaints among a large cohort of EVD survivors. Compared to some other viral infections, synovitis seems rare. Importantly a strong correlation with depression was found highlighting the impact of pain symptoms among survivors

Disclosure: Y. M. PERS, None; M. SALIOU SOW, None; B. TAVERNE, None; L. MARCH, None; J. F. ETARD, None; M. BARRY, None; A. TOURE, None; E. DELAPORTE, None.

To cite this abstract in AMA style:

PERS YM, SALIOU SOW M, TAVERNE B, MARCH L, ETARD JF, BARRY M, TOURE A, DELAPORTE E. Characteristics of the Musculoskeletal Symptoms Observed Among Survivors of Ebola Virus Disease (EVD) in the Postebogui Cohort in Guinea [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/characteristics-of-the-musculoskeletal-symptoms-observed-among-survivors-of-ebola-virus-disease-evd-in-the-postebogui-cohort-in-guinea/. Accessed .

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