Session Information
Date: Tuesday, October 23, 2018
Title: Osteoporosis and Metabolic Bone Disease – Basic and Clinical Science Poster
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose:
Inflammatory arthritis patients had increased risk of atherosclerosis and osteoporosis. The association between presence of carotid plaque and volumetric BMD (vBMD)/microarchitecture is yet to be explored. The aim of this study was to explore the relationship between volumetric bone mineral density (vBMD)/microstructural features and presence of carotid plaque (CP) in patients with inflammatory arthritis.
Methods:
175 inflammatory arthritis patients (81 [46%] PsA, 94 [54%] RA; 70 [40%] males; age: 53 ±12 years) were recruited into an ongoing prospective study assessing the relationship between inflammation, osteoporosis and carotid atherosclerosis. Carotid plaque and intima-media thickness (IMT) were measured by carotid ultrasound. Areal BMD (aBMD) was measured by dual energy X-ray absorptiometry (DXA). Microarchitecture features and vBMD of distal radius were measured using high-resolution peripheral quantitative computed tomography (HR-pQCT).
Results:
No patients had established cardiovascular disease (CVD). Data from 172 patients at baseline were analyzed for this cross-sectional study. Patients were sub grouped according to the presence or absence of carotid plaque (CP+ group, n=68 [40%]) and CP- group, n=132 [60%]). CP+ group were older (59 ±10 vs 49 ±11, p<0.001), more likely to be male (54% vs 31%, p=0.002), had higher systolic blood pressure (130±19 vs 124±17 mmHg, p=0.034) and CVD risk (15.7±14.2 vs 7.9±8.6, p<0.001) according to the Framingham Risk Score (FRS) then the CP- group. aBMD, vBMD and microarchitecture were significantly compromised in the CP+ group. Distal radius aBMD, distal radius total vBMD, trabecular (Tb) vBMD, Tb thickness, cortical (Ct.) vBMD, Ct. thickness and bone volume fraction were 5% (p=0.004), 12% (p<0.001), 8% (p=0.007), 8% (p=0.004), 4% (p=0.007), 10% (p=0.001) and 8% (p=0.007) lower in the CP+ group. The differences remained significant after adjustment for gender, disease type and FRS (Table 1).
Conclusion:
Inflammatory arthritis patients with carotid plaque had lower aBMD, vBMD and compromised bone microarchitecture in the distal radius even after adjustment for gender, disease type and FRS, suggesting that inflammation may be the common link for both conditions.
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Table – Distal radius vBMD/microarchitecture and presence of plaque |
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|
Carotid plaque |
p value |
Adjusted p value* |
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|
No (n=104) |
Yes (n=68) |
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|
Total radius |
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|
aBMD, g/cm2 |
.575 |
± |
.087 |
.547 |
± |
.091 |
0.095 |
0.004 |
|
Distal radius |
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|
Total vBMD, mmHA/cm3 |
353.8 |
± |
77.8 |
315.3 |
± |
69.7 |
0.001 |
<0.001 |
|
Trabecular BMD, mmHA/cm3 |
141.5 |
± |
46.2 |
131.4 |
± |
38.8 |
0.138 |
0.007 |
|
Bone volume fraction |
.118 |
± |
.039 |
.110 |
± |
.032 |
0.142 |
0.007 |
|
Trabecular thickness, mm |
.077 |
± |
.017 |
.071 |
± |
.013 |
0.019 |
0.004 |
|
Cortical vBMD, mmHA/cm3 |
902.6 |
± |
58.0 |
870.0 |
± |
63.5 |
0.001 |
0.007 |
|
Cortical Thickness, mm |
.882 |
± |
.177 |
.792 |
± |
.211 |
0.009 |
0.001 |
|
* Adjusted for gender, disease type and Framingham Risk Score
|
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To cite this abstract in AMA style:
Cheng IT, Shang Q, Li EKM, Wong P, Kun EW, Li M, Li TK, Zhu TY, Lee PA, Qin L, Tam LS. Carotid Atherosclerosis Is Associated with Compromised Volumetric Bone Mineral Density and Microarchitecture in Patients with Inflammatory Arthritis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/carotid-atherosclerosis-is-associated-with-compromised-volumetric-bone-mineral-density-and-microarchitecture-in-patients-with-inflammatory-arthritis/. Accessed .« Back to 2018 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/carotid-atherosclerosis-is-associated-with-compromised-volumetric-bone-mineral-density-and-microarchitecture-in-patients-with-inflammatory-arthritis/