Cardiac Involvements Are Related to Poor Prognosis in Patients with Takayasu’s Arteritis in China

Yujiao Wang¹, Lili Ma ¹, Yan Yan ², Ying Sun ³, Yongshi Wang ⁴, Xiaomin Dai ¹, Zongfei Ji ⁵, Lingying Ma ¹, Huiyong Chen ³ and Lindi Jiang ¹, ¹Zhongshan Hospital, Fudan University, Shanghai, China (People's Republic), ²Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China, Shanghai, China (People's Republic), ³Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China, Shanghai, ⁴Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, P. R. China, Shanghai, ⁵Department of Rheumatology, Zhongshan hospital, Fudan University, Shanghai, China (People's Republic)

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: cardiac structure and follow up, Takayasu.s arteritis

Session Information

Date: Sunday, November 10, 2019

Title: Vasculitis – Non-ANCA-Associated & Related Disorders Poster I: Takayasu's Arteritis & Polymyalgia Rheumatica

Session Type: Poster Session (Sunday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Heart involvements are closely associated with prognosis in patients with Takayasu’s arteritis (TA). This study was aimed to assess the long-term adverse outcomes of cardiac structure and function and their underlying risk factors in TA.

Methods: One hundred and ninety-eight patients, diagnosed as TA, at the Department of Rheumatology, Zhongshan Hospital from January 2012 to December 2017 were recruited in the present study. Patients were divided into normal, mild and severe groups based on the severity of cardiac structure and function impairment. Data, including demographics, clinical characteristics, treatment at baseline, and cardiac outcomes during long-term follow-up were collected.

Results: 60.1% (119/198) patients exhibited heart involvement on echocardiography. 70.6% (84/119) and 79.8% (95/119) cases showed pathological valvular and atrioventricular abnormalities, respectively. The median follow-up duration of patients with heart involvement was 14.25 (8.47-24.92) months, and more than two echocardiography were performed. 3 cases of death were noted. That onset age (p=0.005) and baseline interleukin-6 level (p= 0.031) were risk factors for the deterioration of cardiac structure. Using normal group as a reference, the risk of worsening cardiac structure (p< 0.001) and function (p< 0.001) was greatest in the severe group, with hazard ratios (HRs) of 13.2 (95% CI, 4.4–39.5) and 52.6 (95% CI, 6.8–403.9)respectively, which mostly occurred within 2 years after onset.

Conclusion: The prognosis of TA patients with severe cardiac structure and function impairment is relatively poor, particularly during the first 2 years after onset.

Table1

Table 1. Echocardiographic values in patients with Takayasu arteritis in different groups.

Table2

Table 2. Comparison of clinical features at baseline among different groups.

figure 4

Figure 4. Survival curve indicating the deterioration rate of cardiac structure in the normal, mild and severe groups.

Disclosure: Y. Wang, None; L. Ma, None; Y. Yan, None; Y. Sun, None; Y. Wang, None; X. Dai, None; Z. Ji, None; L. Ma, None; H. Chen, None; L. Jiang, None.

To cite this abstract in AMA style:

Wang Y, Ma L, Yan Y, Sun Y, Wang Y, Dai X, Ji Z, Ma L, Chen H, Jiang L. Cardiac Involvements Are Related to Poor Prognosis in Patients with Takayasu’s Arteritis in China [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/cardiac-involvements-are-related-to-poor-prognosis-in-patients-with-takayasus-arteritis-in-china/. Accessed .

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