Bone Microarchitecture and Bone Strength in Patients with Primary Sjögren's Syndrome: A Case-Control Study Using HR-pQCT

Sandra Gofinet Pasoto¹, Kristopherson Lustosa Augusto¹, Jackeline Couto Alvarenga², Liliam Takayama¹, Valéria Caparbo³, Ricardo M. Oliveira⁴, Eloisa Bonfá¹ and Rosa M R Pereira¹, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴RDO Diagnósticos Médicos, São Paulo, Brazil

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: fractures and osteoporosis, HR-pQCT, Sjogren's syndrome

Session Information

Date: Tuesday, November 10, 2015

Title: Sjögren's Syndrome: Translational Insights into Sjögren's Syndrome

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: To evaluate bone mineral density (BMD), microarchitecture, strength and prevalence of vertebral fractures (VF) in primary Sjögren’s syndrome (pSS).

Methods:

We evaluated 71 female pSS patients and 71 healthy age-, race-matched women. In this case-control study, demographic and clinical data including the risk factors for osteoporosis (OP)/fragility fractures were collected through a standardized protocol. BMD and VF were analyzed by dual-energy X-ray absorptiometry (DXA). Bone microarchitecture was assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) at radius and tibia.

Results:

Patients and controls had comparable age, body mass index, daily calcium intake, smoking, menopausal status and family history of hip fracture (p>0.05). OP/low BMD for age (33.8% vs. 5.6%, p<0.0001) and FV (19.7% vs. 5.6%, p=0.043) were more frequent in patients than controls. In addition, HR-pQCT showed deterioration of cortical and trabecular microarchitecture components and strength at radius, and a deficit on cortical compartment at tibia (p<0.05) in pSS patients compared to controls. Further analysis revealed that prednisone use duration, and deterioration of bone microarchitecture on cortical and trabecular components and strength were significantly higher in pSS patients with OP/low BMD for age than pSS patients without OP/low BMD for age (p<0.05). Multivariate logistic regression analysis revealed that these alterations in bone microarchitecture and strength were independent factors associated with OP/low BMD for age (p<0.05). pSS patients with VF presented cortical bone deterioration (density and thickness) compared with pSS patients without VF (p<0.05).

Conclusion: This study shows increased frequencies of OP and VF associated with cortical and trabecular bone microarchitecture and strength deterioration in pSS. The identification that cortical deterioration is the most important abnormality detected by HR-pQCT in patients with VF suggests that this parameter may be involved in pathogenesis of VF in pSS.

Disclosure: S. G. Pasoto, None; K. L. Augusto, None; J. C. Alvarenga, None; L. Takayama, None; V. Caparbo, None; R. M. Oliveira, None; E. Bonfá, None, 2; R. M. R. Pereira, None, 2.

To cite this abstract in AMA style:

Pasoto SG, Augusto KL, Alvarenga JC, Takayama L, Caparbo V, Oliveira RM, Bonfá E, Pereira RMR. Bone Microarchitecture and Bone Strength in Patients with Primary Sjögren’s Syndrome: A Case-Control Study Using HR-pQCT [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/bone-microarchitecture-and-bone-strength-in-patients-with-primary-sjgrens-syndrome-a-case-control-study-using-hr-pqct/. Accessed .

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