ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1224

BONE Metabolism in LIVER Transplant Patients Two-Year Study. Influence of Medical Intervention PRIOR to Surgery and Antiresorptive Treatment

Eztizen Labrador Sanchez1, Elena Grau Garcia1, Karla Arevalo Ruales1, Jorge Juan Fragio Gil1, Roxana Gonzalez Mazario1, Cristina Alcañiz Escandell1, Ines Canovas Olmos1, Inmaculada Chalmeta Verdejo1, Carlos Feced Olmos1, Luis Gonzalez Puig1, Jose Ivorra Cortes1, Isabel Martinez Cordellat1, Carmen Najera Herranz1, Rosa Negueroles Albuixech1, Jose Eloy Oller Rodriguez1, Francisco Miguel Ortiz-Sanjuán1, Elvira Vicens Bernabeu1, Victoria Fornes Ferrer2, David Hervás Marín2, Marta De la Rubia Navarro1, Angel Moya Herraiz3 and Jose Andres Roman Ivorra1, 1Rheumatology Department. Hospital Universitario y Politecnico La Fe, Valencia, Spain, 2Biostatistics Unit. IIS La Fe, Valencia, Spain, 3Hepatology Department. Hospital Universitario y politecnico La Fe, Valencia, Spain

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: , ,

Session Information

Date: Monday, November 6, 2017

Title: Osteoporosis and Metabolic Bone Disease – Clinical Aspects and Pathogenesis Poster II

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:

Osteoporosis is a frequent complication in patients with chronic liver diseases, mainly in advanced stages or with evidence of cholestasis. During the first few months after liver transplant (LT) it seems that there is an accelerated bone mass loss and greater fracture risk. The aim of the present study is to evaluate the antiresorptive treatment effect in bone metabolism in patients undergoing LT and to evaluate whether medical intervention prior to LT decreases the risk of osteoporosis.

Methods: We recruited patients from the LT Protocol of Osteoporotic Risk Assessment. The patients were evaluated 3-6 months before surgery, shortly after transplant (month 0) and 6-12-18-24 months after surgery. Data of bone metabolism biomarkers, densitometric values and antiresorptive treatment was collected. Biostatistical analysis with R (3.3.2.) was performed.

Results: We selected 163 LT patients of which 86 completed 24 months follow-up. From the total cohort, 77.8% were men and the mean age at transplantation 54.53 ±9.4 years old. 92.6% of patients were supplemented with vitamin D after surgery and 19.6% initiated antiresorptive treatment. We observed that 25-OHVitamin D, PTH, beta-CTX and P1NP levels were corrected through the follow-up .T-score during the first year of follow-up decreased slightly and at 24 months the tendency was towards increase. This pattern was stronger in lumbar spine (t-score -1.48±1.34 after surgery and -1.28±1.06 at 24 months). Statistical analysis showed that antiresorptive treatment significantly influence lumbar and hip densitometric values (P<0.001 and P<0.001 respectively) as well as P1NP levels (P=0.003 and P=0.012 respectively). Moreover, obesity (P=0.0004), as well as beta-CTX (P=0.029) and 25-OHVitamin D (P=0.024) standardization improved hip densitometric values. Finally, LT patients evaluated before surgery showed better lumbar densitometric values than those evaluated after the transplant (P=0.007).

Conclusion: We observed 25-OHVitamin D levels and bone metabolism biomarkers correction during the first two years after LT. Medical intervention prior to LT as well as antiresorptive treatment seem to play a decisive role in bone mineral density improvement.

Disclosure: E. Labrador Sanchez, None; E. Grau Garcia, None; K. Arevalo Ruales, None; J. J. Fragio Gil, None; R. Gonzalez Mazario, None; C. Alcañiz Escandell, None; I. Canovas Olmos, None; I. Chalmeta Verdejo, None; C. Feced Olmos, None; L. Gonzalez Puig, None; J. Ivorra Cortes, None; I. Martinez Cordellat, None; C. Najera Herranz, None; R. Negueroles Albuixech, None; J. E. Oller Rodriguez, None; F. M. Ortiz-Sanjuán, None; E. Vicens Bernabeu, None; V. Fornes Ferrer, None; D. Hervás Marín, None; M. De la Rubia Navarro, None; A. Moya Herraiz, None; J. A. Roman Ivorra, None.

To cite this abstract in AMA style:

Labrador Sanchez E, Grau Garcia E, Arevalo Ruales K, Fragio Gil JJ, Gonzalez Mazario R, Alcañiz Escandell C, Canovas Olmos I, Chalmeta Verdejo I, Feced Olmos C, Gonzalez Puig L, Ivorra Cortes J, Martinez Cordellat I, Najera Herranz C, Negueroles Albuixech R, Oller Rodriguez JE, Ortiz-Sanjuán FM, Vicens Bernabeu E, Fornes Ferrer V, Hervás Marín D, De la Rubia Navarro M, Moya Herraiz A, Roman Ivorra JA. BONE Metabolism in LIVER Transplant Patients Two-Year Study. Influence of Medical Intervention PRIOR to Surgery and Antiresorptive Treatment [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/bone-metabolism-in-liver-transplant-patients-two-year-study-influence-of-medical-intervention-prior-to-surgery-and-antiresorptive-treatment/. Accessed .

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/bone-metabolism-in-liver-transplant-patients-two-year-study-influence-of-medical-intervention-prior-to-surgery-and-antiresorptive-treatment/