ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 0459

Autologous Hematopoietic Stem Cell Transplantation for Behçet’s Disease: A Retrospective Survey of Patients Treated in Europe, on the Behalf of the Autoimmune Diseases Working Party of the European Society for Blood and Bone Marrow Transplantation

Mathieu Puyade1, Patel Amit2, Yeong Jer Lim3, Norbert Blank4, Manuela Badoglio5, Francesca Gualandi6, David D Ma7, Raffaella Greco8, Natalia Maximova9, Tobias Alexander10 and John A Snowden11, 1Service de Médecine Interne et Maladies Infectieuses ,CIC-1402 Centre Hospitalier Universitaire de Poitiers, Poitiers, France, 2The Christie NHS Foundation Trust, Manchester, United Kingdom, 3University of Liverpool, Liverpool, United Kingdom, 4Department of Hematology, Oncology and Rheumatology, Internal Medicine V, University Hospital of Heidelberg, Eppelheim, Germany, 5EBMT ADWP Office, Paris, France, 6U.O. EMATOLOGIA Centro Trapianti Midollo - OSPEDALE POLICLINICO SAN MARTINO, GENOVA, Italy, 7Department of Haematology and BM Transplantation, St Vincent’s Hospital Sydney and St Vincent’s Clinical School, Faculty of Medicine, Sidney, New South Wales, Australia, 8Ematologia Trapianto Midollo San Raffaele, Milano, Italy, 9Institute for Maternal and Child Health – IRCCS Burlo Garofolo, Trieste, Italy, 10Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Deutsches Rheuma-Forschungszentrum, Berlin, Germany, 11Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

Meeting: ACR Convergence 2020

Keywords: Behçet's Syndrome, Disease Activity

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Friday, November 6, 2020

Session Title: Miscellaneous Rheumatic & Inflammatory Diseases I: Mechanisms of Disease (0459–0463)

Session Type: Abstract Session

Session Time: 10:00AM-10:50AM

Background/Purpose: Behçet’s Disease (BD) is a rare autoimmune disease mostly presenting with recurrent oral and genital aphtosis, ulcers, and uveitis. Rare patients are refractory to conventional treatments. Autologous hematological stem cell transplantation (AHSCT) is a standard of care in other autoimmune diseases. Some patients with BD have been treated with AHSCT based on compassionate use.

Methods: Evaluate the outcome of AHSCT in adult patients with BD treated in member centers of the European Society for Blood and Marrow Transplantation (EBMT). Adults who received AHSCT primarily for BD were identified retrospectively in the EBMT registry and/or in published literature. Data were extracted from either medical records of the patient or from publications.

Results: Eight out of 9 cases reported to the registry and extracted data of 2 further patients from literature were analyzed. Four were female, median age at onset of BD was 24y (range 9-50). Median age at AHSCT was 32y (27-51). Patients had received median 4 (2-11) prior lines of therapy (89% corticosteroids, 50% methotrexate, anti-TNFa or cyclophosphamide). All patients had active disease before mobilization. Conditioning regimen was heterogeneous. Median follow-up was 48 months (range 6-240 months). No treatment-related mortality was reported. At last follow-up, one patient did not respond, 3 patients relapsed with pan-uveitis (n=1), aphtosis (n=2) and arthralgia (n=1). Six patients were in CR without any further treatment. No late complications were reported.

Conclusion: AHSCT is feasible and safe in multi-refractory patients with BD and has the potential to stabilize BD in patients with life-threatening involvements.


Disclosure: M. Puyade, None; P. Amit, None; Y. Lim, None; N. Blank, None; M. Badoglio, None; F. Gualandi, None; D. Ma, None; R. Greco, None; N. Maximova, None; T. Alexander, None; J. Snowden, Sanofi, 8, Jazz Pharmaceuticals, 8, Janssenn and Jansenn, 8, Actelion Pharma, 8, Mallinckrodt, 8, Gilead, 8, Kiadis, 6.

To cite this abstract in AMA style:

Puyade M, Amit P, Lim Y, Blank N, Badoglio M, Gualandi F, Ma D, Greco R, Maximova N, Alexander T, Snowden J. Autologous Hematopoietic Stem Cell Transplantation for Behçet’s Disease: A Retrospective Survey of Patients Treated in Europe, on the Behalf of the Autoimmune Diseases Working Party of the European Society for Blood and Bone Marrow Transplantation [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/autologous-hematopoietic-stem-cell-transplantation-for-behcets-disease-a-retrospective-survey-of-patients-treated-in-europe-on-the-behalf-of-the-autoimmune-diseases-working-party-of-the-eur/. Accessed February 28, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to ACR Convergence 2020

ACR Meeting Abstracts - https://acrabstracts.org/abstract/autologous-hematopoietic-stem-cell-transplantation-for-behcets-disease-a-retrospective-survey-of-patients-treated-in-europe-on-the-behalf-of-the-autoimmune-diseases-working-party-of-the-eur/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.