Date: Sunday, October 21, 2018
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: The coexistence of different autoimmune diseases (AID) has been well established in the literature. In our knowledge, there is no study assessing specifically the association between RA and other AID. The aim of our study was to determine the frequency of AID in RA patients and to compare this frequency between patients with and without RA or other rheumatologic AID.
Methods: Multicenter, observational, analytical, retrospective study, including consecutive patients with diagnosis of RA (ACR/EULAR 2010 criteria). Patients with initial diagnosis of primary ostearthritis (OA) were used as control group.
Results: A total of 1549 patients from 23 centers were included: 831 RA [84% women, mean age 55.2 (±13.6)] and 718 OA [82% women, mean age 67 (± 11.1)]. Mean age at RA symptoms onset was 45.5 (± 13.4). Most patients (90.5%) were treated with DMARDs and 34.3% with biologic drugs. The frequency of AID in the RA group was 22% (n=183). RA patients showed higher frequency of rheumatologic AID (9.4 vs 3.3%, p< 0.001), and lower frequency of non-rheumatologic AID than OA patients (15.3 vs 20.5%, p= 0.007). The most frequent rheumatologic AID was Sjögren´s Syndrome (SS), with a higher prevalence in RA patients (87.2 vs 29.2%, p<0.001). There was no difference in the frequency of other pathologies. The frequency of rheumatologic AID in RA patients was higher in those with erosive RA (11 vs 6.8%, p=0.048). No association with gender, age, nodular RA or seropositivity was observed. A lower age at RA diagnosis was associated with lower age at thyroid AID (39 vs 48.2, p=0.0001) and SS diagnosis (41.3 vs 57.1, p< 0.0001). Family history of AID was higher in RA patients (24.4 vs 13.4%, p< 0.001). In the control group, family history of AID was associated with higher frequency of non-rheumatologic AID (36.2 vs 20.9%, p= 0.005), mostly thyroid diseases.
Conclusion: The frequency of AID in RA patients was 22%. Rheumatologic AID were more frequent in RA patients, mostly in those with erosive RA, whereas non-rheumatologic AID prevailed in OA patients. Family history of AID, mainly rheumatologic ones, was higher in RA patients.
To cite this abstract in AMA style:Serrano ER, Sosa J, Kohan MP, Santa Cruz MJ, Medina MA, Klajn DS, Papasidero SB, Caracciolo JÁ, Benegas M, Saturansky E, Quintana R, Pons Estel B, Pereira D, Dellepiane A, García Salinas R, Correa MDLA, Citera G, Sacnun M, Hartvig C, Demarchi J, Bartel G, Gómez A, Kirmayr K, Velasco Zamora J, Chichotky Y, Zalazar MM, Rillo O, Bohr A, Pérez Dávila A, Najera H, Secco A, Chuquimia RJ, Martinez Muñoz A, Buschiazzo E, Juárez RV, Raiti L, Cruzat V, Smichowski A, Casado G, Zelaya DM, Álvarez D, Kerzberg E, Rosa J, García V, Retamozo C, Costi AC, Pena C, Maldonado Ficco H. Association of Rheumatoid Arthritis and Other Autoinmune Diseases [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/association-of-rheumatoid-arthritis-and-other-autoinmune-diseases/. Accessed December 4, 2020.
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