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Abstract Number: 531

Association of Rheumatoid Arthritis and Other Autoinmune Diseases

Eliana Rebeca Serrano1, Julia Sosa2, María Paula Kohan2, María Julia Santa Cruz1, María Alejandra Medina1, Diana Silvia Klajn3, Silvia Beatriz Papasidero4, José Ángel Caracciolo1, Mariana Benegas5, Etel Saturansky6, Rosana Quintana7, Bernardo Pons Estel7, Dora Pereira8, Analía Dellepiane9, Rodrigo García Salinas10, María de los Angeles Correa11, Gustavo Citera12, Mónica Sacnun13, Claudia Hartvig14, Julia Demarchi15, Guillermo Bartel15, Andrea Gómez15, Karin Kirmayr16, José Velasco Zamora17, Yamila Chichotky18, María Marta Zalazar19, Oscar Rillo3, Analía Bohr20, Adriana Pérez Dávila21, Hugo Najera22, Anastasia Secco22, Rene Jearmany Chuquimia22, Alejandro Martinez Muñoz23, Emilio Buschiazzo24, Ricardo Vicente Juárez25, Laura Raiti26, Vanesa Cruzat26, Andrea Smichowski27, Gustavo Casado27, David Marcos Zelaya28, Damaris Álvarez28, Eduardo Kerzberg29, Javier Rosa30, Victoria García31, Cinthya Retamozo32, Ana Carolina Costi33, Claudia Pena34 and Hernán Maldonado Ficco35, 1Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, 2Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, CABA, Argentina, 3Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, CABA, Argentina, 4Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, Buenos Aires, Argentina, 5Rheumatology Section, Sanatorio Dr. Julio Méndez, Buenos Aires, Argentina, 6Rheumatology Section, Sanatorio Dr. Julio Méndez, CABA, Argentina, 7Rheumatology Section, Sanatorio Parque S.A., Rosario, Argentina, 8Rheumatology Section, Hospital Dr. Ricardo Gutiérrez, Argentina, Buenos Aires, Argentina, 9Rheumatology Section, CEMEC, Casilda-Santa Fe, Argentina, 10Rheumatology Section, Hospital Italiano de La Plata, La Plata, Argentina, 11Rheumatology Section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 12Rheumatology Section, Instituto de Rehabilitación Psicofísica, CABA, Argentina, 13Rheumatology Section, Hospital Provincial de Rosario, Rosario, Argentina, 14Rheumatology Section, Hospital Provincial de Rosario, Rosario-Santa Fe, Argentina, 15Rheumatology Section, Hospital Británico de Buenos Aires, CABA, Argentina, 16Rheumatology Section, Sanatorio San Carlos de Bariloche, Bariloche, Argentina, 17Rheumatology Section, Reumatologia al Sur, Berazategui- Buenos Aires, Argentina, 18Rheumatology Section, Reumatologia al sur, Berazategui- Buenos Aires, Argentina, 19Rheumatology Section, Hospital General de Agudos Dr. Ignacio Pirovano, Buenos Aires, Argentina, 20Rheumatology Section, Hospital de Rehabilitación Manuel Rocca, Buenos Aires, Argentina, 21Rheumatology Section, Hospital de Rehabilitación Manuel Rocca, CABA, Argentina, 22Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, 23Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, San Miguel- Buenos Aires, Argentina, 24Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, 25Rheumatology Section, Hospital Señor del Milagro de Salta, Salta, Argentina, 26Rheumatology Section, Clínica Bessone, San Miguel- Buenos Aires, Argentina, 27Rheumatology Section, Hospital Militar Central, CABA, Argentina, 28Rheumatology Section, Hospital General de Agudos José María Ramos Mejía, CABA, Argentina, 29Rheumatology Section, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina, 30Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Capital Federal, Argentina, 31Rheumatology Section, Hospital Italiano de Buenos Aires, CABA, Argentina, 32Rheumatology Section, Centro Especializado Diabetes y Reumatologia, Orán- Salta, Argentina, 33Rheumatology Section, Hospital Interzonal General de Agudos Gral. José de San Martín, La Plata, Buenos Aires, Argentina, 34Rheumatology Section, Hospital San Martín de La Plata, La Plata- Buenos Aires, Argentina, 35Rheumatology Section, Hospital San Antonio de Padua, Río Cuarto- Córdoba, Argentina

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: autoimmune diseases and rheumatoid arthritis (RA)

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Session Information

Date: Sunday, October 21, 2018

Title: Rheumatoid Arthritis – Diagnosis, Manifestations, and Outcomes Poster I: Comorbidities

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: The coexistence of different autoimmune diseases (AID) has been well established in the literature. In our knowledge, there is no study assessing specifically the association between RA and other AID. The aim of our study was to determine the frequency of AID in RA patients and to compare this frequency between patients with and without RA or other rheumatologic AID.

Methods: Multicenter, observational, analytical, retrospective study, including consecutive patients with diagnosis of RA (ACR/EULAR 2010 criteria). Patients with initial diagnosis of primary ostearthritis (OA) were used as control group.

Results: A total of 1549 patients from 23 centers were included: 831 RA [84% women, mean age 55.2 (±13.6)] and 718 OA [82% women, mean age 67 (± 11.1)]. Mean age at RA symptoms onset was 45.5 (± 13.4). Most patients (90.5%) were treated with DMARDs and 34.3% with biologic drugs. The frequency of AID in the RA group was 22% (n=183). RA patients showed higher frequency of rheumatologic AID (9.4 vs 3.3%, p< 0.001), and lower frequency of non-rheumatologic AID than OA patients (15.3 vs 20.5%, p= 0.007). The most frequent rheumatologic AID was Sjögren´s Syndrome (SS), with a higher prevalence in RA patients (87.2 vs 29.2%, p<0.001). There was no difference in the frequency of other pathologies. The frequency of rheumatologic AID in RA patients was higher in those with erosive RA (11 vs 6.8%, p=0.048). No association with gender, age, nodular RA or seropositivity was observed. A lower age at RA diagnosis was associated with lower age at thyroid AID (39 vs 48.2, p=0.0001) and SS diagnosis (41.3 vs 57.1, p< 0.0001). Family history of AID was higher in RA patients (24.4 vs 13.4%, p< 0.001). In the control group, family history of AID was associated with higher frequency of non-rheumatologic AID (36.2 vs 20.9%, p= 0.005), mostly thyroid diseases.

Conclusion: The frequency of AID in RA patients was 22%. Rheumatologic AID were more frequent in RA patients, mostly in those with erosive RA, whereas non-rheumatologic AID prevailed in OA patients. Family history of AID, mainly rheumatologic ones, was higher in RA patients.


Disclosure: E. R. Serrano, None; J. Sosa, None; M. P. Kohan, None; M. J. Santa Cruz, None; M. A. Medina, None; D. S. Klajn, None; S. B. Papasidero, None; J. Á. Caracciolo, None; M. Benegas, None; E. Saturansky, None; R. Quintana, None; B. Pons Estel, None; D. Pereira, None; A. Dellepiane, None; R. García Salinas, None; M. D. L. A. Correa, None; G. Citera, Novartis, Pfizer Inc, 2,AbbVie, Bristol-Myers Squibb, Eli Lilly, Genzyme, Novartis, Pfizer Inc, Roche, 5; M. Sacnun, None; C. Hartvig, None; J. Demarchi, None; G. Bartel, None; A. Gómez, None; K. Kirmayr, None; J. Velasco Zamora, None; Y. Chichotky, None; M. M. Zalazar, None; O. Rillo, None; A. Bohr, None; A. Pérez Dávila, None; H. Najera, None; A. Secco, None; R. J. Chuquimia, None; A. Martinez Muñoz, None; E. Buschiazzo, None; R. V. Juárez, None; L. Raiti, None; V. Cruzat, None; A. Smichowski, None; G. Casado, None; D. M. Zelaya, None; D. Álvarez, None; E. Kerzberg, None; J. Rosa, None; V. García, None; C. Retamozo, None; A. C. Costi, None; C. Pena, None; H. Maldonado Ficco, None.

To cite this abstract in AMA style:

Serrano ER, Sosa J, Kohan MP, Santa Cruz MJ, Medina MA, Klajn DS, Papasidero SB, Caracciolo JÁ, Benegas M, Saturansky E, Quintana R, Pons Estel B, Pereira D, Dellepiane A, García Salinas R, Correa MDLA, Citera G, Sacnun M, Hartvig C, Demarchi J, Bartel G, Gómez A, Kirmayr K, Velasco Zamora J, Chichotky Y, Zalazar MM, Rillo O, Bohr A, Pérez Dávila A, Najera H, Secco A, Chuquimia RJ, Martinez Muñoz A, Buschiazzo E, Juárez RV, Raiti L, Cruzat V, Smichowski A, Casado G, Zelaya DM, Álvarez D, Kerzberg E, Rosa J, García V, Retamozo C, Costi AC, Pena C, Maldonado Ficco H. Association of Rheumatoid Arthritis and Other Autoinmune Diseases [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/association-of-rheumatoid-arthritis-and-other-autoinmune-diseases/. Accessed .
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