ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1868

Association between Brain-Derived Neurotrophic Factor Gene Polymorphisms and Fibromyalgia in a Korean Population: A Multi-Center Study

Ji-Hyoun Kang1, Kyung-Eun Lee2, Dong-Jin Park1, Seong-Ho Kim3, Seong-Su Nah4, Ji Hyun Lee5, Seong-Kyu Kim6, Yeon-Ah Lee7, Seung-Jae Hong8, Hyun-Sook Kim9, Hye-Soon Lee10, Hyoun-Ah Kim11, Chung-Il Joung12, Sang-Hyon Kim13 and Shin-Seok Lee1, 1Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South), 2Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South), 3Inje University Haeundae Paik Hospital, Busan, Korea, Republic of (South), 4Soonchunhyang University, College of Medicine, Cheonan, Korea, Republic of (South), 5Maryknoll Medical Center, Busan, Korea, Republic of (South), 6Rheumatology, Catholic University of Daegu School of Medicine, Daegu, Korea, Republic of (South), 7Rheumatology, Kyung Hee University Hospital, Seoul, Korea, Republic of (South), 8Dept. of Rheumatology, #1 Hoeg, KyungHee University Medical Center, SEOUL, Korea, Republic of (South), 9Soonchenhyang university school of medicine, Seoul, Korea, Republic of (South), 10Hanyang University Guri Hospital, Gyeonggi-do, Korea, Republic of (South), 11Ajou University Hospital, Suwon, Korea, Republic of (South), 12Konyang University Medical School, Daejeon, Korea, Republic of (South), 13Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea, Daegu, Korea, Republic of (South)

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords:

Session Information

Date: Monday, November 6, 2017

Title: Fibromyalgia, Soft Tissue Disorders, Regional and Specific Clinical Pain Syndromes

Session Type: ACR Concurrent Abstract Session

Session Time: 4:30PM-6:00PM

Background/Purpose: Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of fibromyalgia (FM) and studies have found that FM patients have altered serum and plasma BDNF levels. However, it is not known whether polymorphisms of the BDNF gene are associated with FM. In this study, we explored the association between polymorphisms of the BDNF gene with FM susceptibility and the severity of symptoms.

Methods: The study enrolled 409 patients with FM and 423 controls from 10 medical centers that participated in the Korean nationwide FM survey study. Alleles at 10 positions in the BDNF gene were genotyped: rs2883187 (C>T), rs7103873 (G>C), rs7103411(C>T), rs10835210 (C>A), rs11030104 (A>G), rs12273539 (C>T), rs11030102(C>G), rs11030101 (A>T), rs6265 (G>A), and rs7124442(C>T).

Results: The allele and genotype frequencies of BDNF rs11030104 differed significantly between the FM patients and controls (P=0.031). The GG genotype of rs11030104 had a protective role against FM (P=0.016) and the G allele of rs11030104 was negatively associated with the presence of FM compared with the A allele (P=0.013). In comparison, although the allele and genotype frequencies of BDNF rs12273539 did not differ between the FM patients and controls, the TT genotype of BDNF rs12273539 was associated with susceptibility to FM (P=0.038). Haplotype analyses suggested that some BDNF haplotypes have a protective role against FM. Finally, we found that that some genotypes and haplotypes of the BDNF gene contribute to the specific symptoms of FM.

Conclusion: This study is the first to evaluate the associations of BDNF gene polymorphisms with FM. Our results suggest that some BDNF single-nucleotide polymorphisms and haplotypes are associated with susceptibility to, and contribute to the symptoms of, FM.

Disclosure: J. H. Kang, None; K. E. Lee, None; D. J. Park, None; S. H. Kim, None; S. S. Nah, None; J. H. Lee, None; S. K. Kim, None; Y. A. Lee, None; S. J. Hong, None; H. S. Kim, None; H. S. Lee, None; H. A. Kim, None; C. I. Joung, None; S. H. Kim, None; S. S. Lee, None.

To cite this abstract in AMA style:

Kang JH, Lee KE, Park DJ, Kim SH, Nah SS, Lee JH, Kim SK, Lee YA, Hong SJ, Kim HS, Lee HS, Kim HA, Joung CI, Kim SH, Lee SS. Association between Brain-Derived Neurotrophic Factor Gene Polymorphisms and Fibromyalgia in a Korean Population: A Multi-Center Study [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/association-between-brain-derived-neurotrophic-factor-gene-polymorphisms-and-fibromyalgia-in-a-korean-population-a-multi-center-study/. Accessed .

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