Date: Monday, October 22, 2018
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: In order to better discern medication efficacy for CLE, a better understanding of CLE’s impact on quality of life (QoL) in individuals with CLE is required. Further, the use of a theoretical framework allows for the development, validation, and eventual use of patient-reported outcome measures that identify empirical factors significantly impacting QoL of patients with CLE. Thus, the purpose of this study was to examine multiple factors associated with CLE that affect QoL, using the Revised Wilson and Cleary’s Model (WCM) for QoL. The WCM is a disease-based, physiological framework that links biological and physiological factors, symptoms status, functioning, general health perceptions, individual and environmental characteristics, and overall QoL.
Methods: A cross-sectional, correlational study was conducted in 101 CLE patients recruited from an outpatient university-based dermatology clinic in Dallas, Texas. Demographic, clinical
Results: The overall QoL – CLEQoL regression model was significantly different from zero, F=24.96; df.=14, 76; p=<0.001. Approximately 85 percent of the variation in overall QoL (R2=0.85) was accounted for by predictor variables within the WCM model, where the adjusted R2 was 82 percent (R2=0.82). Disease activity (β=0.13, p=0.027), fatigue (β=0.24, p=0.002), and body image (β=0.62, p<0.001) were significant, positive predictors of overall QoL while controlling for other predictor variables (β=0.19, p=0.03). Pain (β=-0.23, p=0.019) and side-effects (β=-0.13, p=0.041) were negative predictors of overall QoL. Patients who experienced higher levels of disease activity, higher fatigue
Conclusion: Hence, in addition to performing thorough skin exams, asking patients about symptoms, body perception, and medication toxicities can aid providers in better understanding CLE’s impact on patients’ QoL. Using a theoretical framework, patient-centered and clinical outcomes were integrated to facilitate a fuller understanding of the several factors impacting QoL in CLE patients. As such, future studies aimed at understanding QoL in CLE patients can consider using a theoretical framework as healthcare becomes more patient-centered.
To cite this abstract in AMA style:Ogunsanya ME, Hudson A, Vasquez R, Chong BF. Assessing a Conceptual Framework of Quality of Life in a Cutaneous Lupus Erythematosus Population [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/assessing-a-conceptual-framework-of-quality-of-life-in-a-cutaneous-lupus-erythematosus-population/. Accessed December 4, 2020.
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