Session Information
Date: Sunday, November 17, 2024
Title: Vasculitis – Non-ANCA-Associated & Related Disorders Poster II
Session Type: Poster Session B
Session Time: 10:30AM-12:30PM
Background/Purpose: Arthritis associated with Behcet’s disease (BD) has been reported to be related to patients’ quality of life and associated with skin and mucosal lesions. However, it is unclear how arthritis activity affects clinical symptoms and quality of life in BD patients. Therefore, we aimed to determine the influence of the presence and activity of arthritis on the severity of BD patients.
Methods: This is a retrospective observational study of BD patients attending our hospital from January 2022 to December 2023. SDAI, CDAI, and DAS28-CRP were used to assess arthritis activity in all subjects with or without arthritis. Disease activity of BD is assessed by clinical symptoms, PGA (Patient’s Global Assessment), EGA (Evaluator’s Global Assessment), BDCAF (Behcet’s Disease Current Activity Form), BSAS (Behcet’s Syndrome Activity Score), BDQOL (Behcet’s Disease Quality of Life scale), and VAS (Visual Analog Scale) for oral ulcers, genital ulcers, and joint pain. Patients were also evaluated twice at one-year intervals to determine the relationship between changes in arthritis activity and BD disease activity.
Results: Of the 54 patients included in the study, 39 were women, and the mean disease duration was 13.9 years(Table). Longer disease duration was associated with lower arthritis activity indices (DAS28-CRP, SDAI, CDAI); BSAS, BDQOL, and BDCAF were positively correlated with arthritis disease activity.
Comparison of disease activity at 1-year intervals showed a significant decrease in the rates of oral ulcers and arthritis, as well as a significant decrease in arthritis activity (SDAI, CDAI, DAS28-CRP). However, BSAS, BDCAF, and BDQOL did not change significantly. BD patients whose arthritis improved over the course of the year also showed improvement in oral ulcers. Similar to BDCAF, BDQOL was significantly lower in relation to decreased arthritis activity, and decreases in SDAI and CDAI correlated with those in BDQOL (SDAI: r=0.41, p=0.007. CDAI: r=0.43, p=0.0049, Figure).
Conclusion: Patients with BD with high arthritis activity had higher overall disease activity and severity of BD. Our results suggest that controlling arthritis activity is one of the important factors to improve quality of life in BD.
To cite this abstract in AMA style:
Sugihara K, Wakiya R, Shimada H, Miyagi T, Ushio Y, Mino R, Mizusaki M, yamaguchi H, Manabe N, Nakashima S, dobashi H. Arthritis Activity Significantly Affects Quality of Life in Behcet’s Disease Patients [abstract]. Arthritis Rheumatol. 2024; 76 (suppl 9). https://acrabstracts.org/abstract/arthritis-activity-significantly-affects-quality-of-life-in-behcets-disease-patients/. Accessed .« Back to ACR Convergence 2024
ACR Meeting Abstracts - https://acrabstracts.org/abstract/arthritis-activity-significantly-affects-quality-of-life-in-behcets-disease-patients/