ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2494

Analysis of the Efficacy, Safety and Continuation Rate of Abatacept in Elderly Patients with Rheumatoid Arthritis

Mayumi Matsuda1, Yu Funakubo Asanuma2, Noritsune Kouzu3 and Toshihide Mimura2, 1Department of Rheumatology and Applied Immunology, Saitama Medical University, Moroyama-machi, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 3Saitama Medical University, Moroyama, Japan

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Abatacept, Efficient, Elderly, rheumatoid arthritis (RA) and safety

  • Tweet
  • Email
  • Print
Session Information

Date: Tuesday, November 7, 2017

Title: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy Poster III: Efficacy and Safety of Originator Biologics and Biosimilars

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: The elderly rheumatoid arthritis (RA) patients have declined physical performances and various complications. The efficacy of the biological DMARDs may decrease in elderly RA patients because not enough dosage of MTX could be used for them, due to some concerns such as risks of the infection increasing. The purpose of this study was to examine the efficacy, safety and continuation rate of abatacept(ABT) in elderly patients with RA.

Methods: sixty-three RA patients who had received ABT in Saitama Medical University Hospital between Oct. 2010 and May 2016 were divided into 2 groups. One was 64 years old and under (n=31), the other was 65 years old and over (n=32). In these 2 groups, we examined the retrospective evaluation of the patients’ background, disease activity, decline in physical performance, reduction of methotrexate (MTX) or prednisolone (PSL) dose, safety and continuation rate of ABT.

Results: In the patients background (younger group/elderly group), mean age of onset (46/60 year-old), rate of female (83.9/84.4%), naïve rate of biological DMARDs (51.6/28.1%), mean disease duration (7.9/12.1 years), rate of MTX use (64.5/37.5% p=0.045), rate of PSL use (64.5/87.5% p=0.041), mean dose of MTX (5.4/3.1mg/week), mean dose of PSL (5.0/5.1mg/day), DAS28-ESR4 (5.53/5.84)、and HAQ (1.13/1.67 p=0.046), positive rate of RF (74.2/93.8% p=0.043) were observed. The elderly group showed higher HAQ (p=0.046) than the younger group. In effectiveness, DAS28-ESR4 and HAQ significantly decreased in both groups for the observational period of one year after initiation of ABT therapy (P<0.05). ABT therapy did not reduce the dose of MTX for one year, while reduction of the dose of PSL was observed in both groups. There were no significant differences in the continuation rate between the younger (87.1%) and the elderly group (75.0%). The cancellation reason of ABT (younger group/elderly group) were due to adverse events (6.5/12.5%), ineffective (6.5/6.3%), remission (0.0/3.1%) one year after ABT started.

Conclusion: The ABT treatment in the elderly RA patients was suggested useful as much as in the younger patients regarding the effectiveness, the reduction of PSL dose, and the continuation rate.


Disclosure: M. Matsuda, None; Y. F. Asanuma, None; N. Kouzu, None; T. Mimura, Abbvie, 5,Astellas, 5,Eisai, 5,Janssen Pharmaceutica Product, L.P., 5,Novartis Pharmaceutical Corporation, 5,Ono Pharma, 5,Pfizer Inc, 5,Sanofi-Aventis Pharmaceutical, 5,Takeda Pharmaceutical, 5,Tanabe-Mitsubishi Pharma, 5.

To cite this abstract in AMA style:

Matsuda M, Asanuma YF, Kouzu N, Mimura T. Analysis of the Efficacy, Safety and Continuation Rate of Abatacept in Elderly Patients with Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/analysis-of-the-efficacy-safety-and-continuation-rate-of-abatacept-in-elderly-patients-with-rheumatoid-arthritis/. Accessed .
  • Tweet
  • Email
  • Print

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/analysis-of-the-efficacy-safety-and-continuation-rate-of-abatacept-in-elderly-patients-with-rheumatoid-arthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology