ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1995

Analysis of Erosion Volume of the Distal Radius By HR-pQCT in Patients with Rheumatoid Arthritis

Ko Chiba1, Naoki Iwamoto2, Makoto Osaki1 and Atsushi Kawakami2, 1Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords:

Session Information

Date: Tuesday, November 7, 2017

Title: Imaging of Rheumatic Diseases Poster II

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

HR-pQCT is a high resolution CT dedicated to human extremities. It has been used mainly for osteoporosis, while in more recent years it has been applied to research in rheumatoid arthritis (RA).

The purpose of this study is to develop a method to quantify the erosion volume of distal radius in patients with RA semiautomatically using second generation HR-pQCT.

Methods:

Ten patients with RA (ave. 66 years, 7 female, 3 male) participated in this study. The wrist joint was scanned using HR-pQCT (XtremeCT II, Scanco Medical, Switzerland) at the voxel size of 61 um.

The erosion volume was measured semiautomatically using the dedicated software (TRI/3D-BON, Ratoc System Engineering, Tokyo).

All concave regions on the bone surface around the distal radius were extracted automatically by subtracting the bone region from the smoothed bone model. Erosions were selected manually by a medical doctor based on certain criteria. The volume of the erosions were measured by voxel counting.

Results:

16 erosions were detected by HR-pQCT, mainly located on the palmar side of the distal radius (palmar: 12, dorsal: 3, radial: 1). The average volume of the erosions was 5.5 mm3, minimum 0.3 mm3, and maximum 20.0 mm3.

Conclusion:

The semiautomatic method to quantify the erosion volume of distal radius in RA patients by HR-pQCT was developed. The opinion as to whether concave regions are pathological erosion or physiological concave, vascular channel or recess of osteophyte is difficult and should be performed by an experienced tester.

Disclosure: K. Chiba, None; N. Iwamoto, None; M. Osaki, None; A. Kawakami, None.

To cite this abstract in AMA style:

Chiba K, Iwamoto N, Osaki M, Kawakami A. Analysis of Erosion Volume of the Distal Radius By HR-pQCT in Patients with Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/analysis-of-erosion-volume-of-the-distal-radius-by-hr-pqct-in-patients-with-rheumatoid-arthritis/. Accessed .

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