ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 0829

Adult Onset Still’s Disease: A Retrospective Study of Objective Manifestations and Outcomes

Caroline Bui1, Tim Collins2, Kumar Venkat3, Napatkamon Ayutyanont2, Kim Vickery4 and Scott Kubomoto2, 1Riverside Community Hospital/University of California Riverside, Riverside, CA, 2Riverside Community Hospital/University of California Riverside, Riverside, 3University of California Riverside/Riverside Community Hospital, Riverside, 4HCA Healthcare, Riverside

Meeting: ACR Convergence 2022

Keywords:

Session Information

Date: Sunday, November 13, 2022

Title: Miscellaneous Rheumatic and Inflammatory Diseases Poster II

Session Type: Poster Session B

Session Time: 9:00AM-10:30AM

Background/Purpose: Adult Onset Still’s Disease (AOSD) is a complex and rare inflammatory disease with life threatening complications. Due to its rarity and wide ranging clinical presentation, there is a lack of data regarding this patient population and their outcomes.

Methods: We retrospectively identified hospitalized patients within the 185 hospital HCA database between 2016-2021 who were aged 18+ with a diagnosis of AOSD via ICD 10 code M06.1. Further data was collected regarding patient demographics, objective lab findings, and outcomes.

Results: We identified 185 patients with AOSD with an incidence rate of 0.16 to 0.21 per 100,000. Mean age was 47 and nearly 70% were female. Objective presentations included elevated inflammatory markers (ESR 55.11 +/- 36.52, CRP 12.26 +/- 27.48, and ferritin 7141.23 +/- 11536.60), leukocytosis (12.15 (+/- 5.86)), and unspecified anemia (23%). Nearly 24% of patients required ICU level of care and overall mortality rate was 3.2%. Data regarding concurrent diagnoses of pneumonia were also included. 11.9% had a coexisting pneumonia which was associated with an increase in ICU admission (likelihood ratio 7.4, p = 0.007) but not an increase in mortality.

Conclusion: Our study establishes patient demographics and common objective findings to better understand and diagnose this rare disease. Incidence rates increased over time, suggesting increased awareness and improved diagnosis. Our data was consistent with prior studies suggesting that AOSD more commonly affects caucasian females. Objective data also further solidified known lab abnormalities in this group including elevated inflammatory markers, leukocytosis, and anemia. Prior studies have suggested that concomitant pneumonia caused greater severity of disease with increased mortality. This differed in our population, although our study was limited by lack of follow-up data. Further studies may analyze patients who fit Yamaguchi criteria as well as complications and long term outcomes.

Disclosures: C. Bui, None; T. Collins, None; K. Venkat, None; N. Ayutyanont, None; K. Vickery, None; S. Kubomoto, None.

To cite this abstract in AMA style:

Bui C, Collins T, Venkat K, Ayutyanont N, Vickery K, Kubomoto S. Adult Onset Still’s Disease: A Retrospective Study of Objective Manifestations and Outcomes [abstract]. Arthritis Rheumatol. 2022; 74 (suppl 9). https://acrabstracts.org/abstract/adult-onset-stills-disease-a-retrospective-study-of-objective-manifestations-and-outcomes/. Accessed .

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