ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2064

Aberrant Distribution and Function of Plasmacytoid Dendritic Cells in Patients with Ankylosing Spondylitis Are Associated with Unfolded Protein Response

Liu Chin-Hsiu1, Chen Chun-Hsiung1 and Lin Kuo-I2, 1Division of Allergy, Immunology and Rheumatology, Division of Allergy, Immunology and Rheumatology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan., New Taipei city, Taiwan, 2Genomics Research Center, Academia Sinica, Taipei, Taiwan., Taipei city, Taiwan

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Ankylosing spondylitis (AS) and dendritic cells

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Date: Tuesday, October 23, 2018

Title: Spondyloarthritis Including Psoriatic Arthritis – Basic Science Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Although human leukcocyte antigen (HLA)-B27 is strongly associated with ankylosing spondylitis (AS) and HLA-B27 misfolding induces unfolded protein response (UPR), whether UPR is associated with AS remains controversial. It has been speculated that UPR might occur in more specific immune cells. Since dendritic cells (DCs) are crucial in induction and maintenance of AS in HLA-B27-transgenic rat, and plasmacytoid DCs (pDCs) belong to one type of DCs, we here aim to study the relevance of plasmacytoid DCs (pDCs) in AS and explore if UPR in pDCs contributes to the pathogenesis of AS.

Methods: Peripheral pDCs were isolated from 43 AS patients and 39 controls. The bone marrow (BM) and synovium of inflamed hips from AS patients and controls were obtained. Functional and phenotypic analyses of pDCs and their relationship with UPR was investigated.

Results: We found a significantly higher frequency of pDCs in the peripheral blood, BM and inflamed synovium of hips in AS patients. Functional analysis further revealed that the inflammatory cytokines secreted by isolated peripheral pDCs were significantly increased in AS patients compared with those in normal controls. Remarkably, binding immunoglobulin protein (BIP) and protein kinase RNA-like endoplasmic reticulum kinase (PERK) pathway in UPR were up-regulated in unstimulated pDCs of AS patients. Of note, PERK inhibitor treatment significantly inhibited the enhanced cytokine production by pDCs isolated from peripheral blood of AS patients. Furthermore, the extent of PERK activation was significantly associated with the increased disease severity of AS patients, the increased expression of pDC development marker, FMS-like tyrosine kinase (FLT) 3, and tissue homing marker, chemokine receptor (CCR) 6, of pDCs in AS patients.

Conclusion: Our data uncover that the activation of UPR may occur in pDCs of AS patients. The up-regulated PERK pathway in pDCs not only contributes to the aberrant synovial distribution and enhanced inflammatory function of pDCs in AS patients, but also is associated with systemic disease activity of AS patients.


Disclosure: L. Chin-Hsiu, None; C. Chun-Hsiung, None; L. Kuo-I, None.

To cite this abstract in AMA style:

Chin-Hsiu L, Chun-Hsiung C, Kuo-I L. Aberrant Distribution and Function of Plasmacytoid Dendritic Cells in Patients with Ankylosing Spondylitis Are Associated with Unfolded Protein Response [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/aberrant-distribution-and-function-of-plasmacytoid-dendritic-cells-in-patients-with-ankylosing-spondylitis-are-associated-with-unfolded-protein-response/. Accessed .
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/aberrant-distribution-and-function-of-plasmacytoid-dendritic-cells-in-patients-with-ankylosing-spondylitis-are-associated-with-unfolded-protein-response/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology