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Abstract Number: 1589

A Multicriteria Decision Analysis for the Development of New Systemic Lupus Erythematosus Classification Criteria

Sara K. Tedeschi1, Sindhu Johnson2, Dimitrios Boumpas3, David I. Daikh4, Betty Diamond5, Thomas Doerner6, Søren Jacobsen7, Diane L. Kamen8, W. Joseph McCune9, Marta Mosca10, Rosalind Ramsey-Goldman11, Guillermo Ruiz-Irastorza12, Matthias Schneider13, Josef S. Smolen14, Murray Urowitz15, David Wofsy16, Martin Aringer17, Raymond P. Naden18 and Karen H. Costenbader19,20, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, 3University of Athens, Athens, Greece, 4Rheumatology, UCSF/VA Medical Center, San Francisco, CA, 5Feinstein Institute for Medical Research, Manhasset, NY, 6Charité Universitätmedizin Berlin and DRFZ, Berlin, Germany, 7Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 8Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 9Int Med/ Rheum, University of Michigan, Ann Arbor, MI, 10Rheumatology Unit, University of Pisa, Pisa, Italy, 11FSM, Northwestern University, Chicago, IL, 12Autoimmune Diseases Research Unit, BioCruces, Hospital Universitario Cruces, Baracaldo, Spain, 13Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, 14Division of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, 15Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 16Rheumatology, UCSF, San Francisco, CA, 17Medicine III, University Medical Center and Faculty of Medicine at the TU Dresden, Dresden, Germany, 18New Zealand Ministry of Health, New Zealand Ministry of Health, Auckland, New Zealand, 19Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 20Rheumatology, Immunology & Allergy, Brigham & Women's Hospital, Boston, MA

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: classification criteria, decision analysis and systemic lupus erythematosus (SLE)

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Session Information

Date: Monday, November 6, 2017

Title: Systemic Lupus Erythematosus – Clinical Aspects and Treatment Poster II: Damage and Comorbidities

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:

EULAR and ACR are supporting multi-phase development of SLE classification criteria based on weighted criteria and a continuous probability scale. Prior steps included criteria generation, criteria reduction through Delphi and Nominal Group Technique exercises, literature review for sensitivity/specificity of candidate criteria, and organization of candidate criteria into seven clinical and three immunologic domains. Our next goals were to refine definitions of candidate criteria, determine relative weights using multicriteria decision analysis (MCDA), and identify a threshold score on a continuous scale for SLE classification.

Methods:

An SLE Expert Panel (9 North American, 8 European) submitted 167 unique cases, with range of SLE probability. Experts scored 20 representative cases using the candidate criteria and rank-ordered them. In a two day meeting, experts reviewed inter-rater reliability of scoring, refined criteria definitions, and participated in a MCDA exercise using 1000MindsTM software. Experts were presented with a series of decisions between two cases, each with different criteria from two domains (e.g. oral ulcers [cutaneous] and acute pericarditis [serositis] vs. alopecia [cutaneous] and pleural effusion [serositis]). Experts anonymously voted for the case more likely to be classified as SLE. Votes were discussed until consensus was reached for each decision. Using the consensus decisions, 1000MindsTM calculated criteria weights, assigned a total score to each of remaining 147 cases and rank-ordered the cases. Experts voted on whether each case should be classified as SLE. The score of the last case for which consensus was achieved was the threshold score. Experts repeated the MCDA for criteria whose calculated weights were inconsistent with expert opinion until group consensus was achieved.

Results:

Inter-rater reliability was good; human data entry error, not following instructions, and differing interpretations of criteria definitions accounted for discrepancies. Arthritis and pericarditis definitions were modified through group discussion. The MCDA involved 74 pairwise decisions. Cranial neuropathy and Class VI lupus nephritis were removed as they added little to SLE classification. MCDA was repeated for the arthritis and cutaneous domains as initial weights did not match expert opinion. Criteria weights and scores were re-calculated. Experts reached consensus for SLE classification for case scores >83.

Conclusion:

Using an iterative process, the expert panel refined and weighted candidate criteria definitions and determined a threshold score of >83 for SLE classification. Validation is the next step.


Disclosure: S. K. Tedeschi, None; S. Johnson, None; D. Boumpas, None; D. I. Daikh, None; B. Diamond, None; T. Doerner, None; S. Jacobsen, None; D. L. Kamen, None; W. J. McCune, None; M. Mosca, None; R. Ramsey-Goldman, None; G. Ruiz-Irastorza, None; M. Schneider, None; J. S. Smolen, None; M. Urowitz, None; D. Wofsy, None; M. Aringer, None; R. P. Naden, None; K. H. Costenbader, None.

To cite this abstract in AMA style:

Tedeschi SK, Johnson S, Boumpas D, Daikh DI, Diamond B, Doerner T, Jacobsen S, Kamen DL, McCune WJ, Mosca M, Ramsey-Goldman R, Ruiz-Irastorza G, Schneider M, Smolen JS, Urowitz M, Wofsy D, Aringer M, Naden RP, Costenbader KH. A Multicriteria Decision Analysis for the Development of New Systemic Lupus Erythematosus Classification Criteria [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/a-multicriteria-decision-analysis-for-the-development-of-new-systemic-lupus-erythematosus-classification-criteria/. Accessed .
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