Date: Monday, October 22, 2018
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: A decline in the frequency of AA amyloidosis secondary to RA and infectious diseases has been reported. This is probably due to more effective treatment strategies. We had previously reported that although amyloidosis occurs in less than 0.5% of BS pts. It is one of the leading causes of death (1-3). We aimed to determine the change in the frequency of AA amyloidosis over years in BS pts in addition to elaborating on clinical characteristics and outcome.
Methods: We performed a chart review to identify all pts with amyloidosis in our BS center since1976. We noted demographic characteristics, BS manifestations, age at BS and AA amyloidosis diagnosis, treatment modalities of these pts. Our endpoints were death and
Results: Among our 9410 BS pts, 27 (0.29%) had amyloidosis. We identified 24 pts with amyloidosis among the 3820 pts in the earlier cohort and 3 additional
AA amyloidosis appears to be a rare, but fatal complication of BS. Around 50% of pts died after a median follow-up of 3 yrs after amyloidosis. This study showed a decreasing trend of amyloidosis due to BS similar to that observed in other inflammatory and infectious causes. The shorter follow-up duration may be contributing for the lower prevalence of amyloidosis in the recent cohort.
1)Yurdakul S,Arthritis Rheum.1990 2)Melikoğlu M,Rheumatology (Oxford).2001 3)Kural-Seyahi E,Medicine (Baltimore).2003
To cite this abstract in AMA style:Karatemiz G, Esatoglu SN, Ozguler Y, Yurdakul S, Hamuryudan V, Melikoglu M, Fresko I, Seyahi E, Ugurlu S, Ozdogan H, Yazici H, Hatemi G. A Declining Trend in Frequency of Secondary Amyloidosis in Behçet’s Syndrome [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/a-declining-trend-in-frequency-of-secondary-amyloidosis-in-behcets-syndrome/. Accessed December 2, 2020.
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