Session Information
Title: Pediatric Rheumatology: Clinical and Therapeutic Disease II: Juvenile Idiopathic Arthritis II
Session Type: Abstract Submissions (ACR)
Background/Purpose:
Systemic arterial properties in adult patients with JIA are not well described. The aim of this study was to evaluate arterial properties in young adults with JIA compared with age- and sex-matched controls.
Methods:
Nineteen patients (37.7±3.4 years) were randomly selected from a cohort of 88 JIA-patients who were followed from their first referral to Oslo University Hospital in 1980 -85 and had active disease more than 14 years after disease onset. Of the 19 patients, 2 had systemic JIA, 3 polyarticular RF negative, 1 polyarticular RF positive, 3 oligoarticular persistent, 5 oligoarticular extended, 3 enthesitis related, 1 psoriasis arthritis and 1 had undifferentiated arthritis. The patients were investigated after a mean disease duration of 29.2 ±1.3 years and compared with 19 age- and sex-matched controls.
Aortic root pressure and flow data were obtained non invasively by brachial arterial blood pressure, calibrated carotid arterial pulse trace and aortic annular Doppler flow recordings. The systemic arterial properties were described by the total arterial compliance (C), characteristic aortic impedance (Z0), and peripheral arterial resistance (R) obtained from estimation of 3-element windkessel model (WK) parameters (C, Z0, R), by Fourier analyses of central aortic pressure and flow data (Z0).
Results: (table)
The proximal aortic stiffness, evaluated by Z0,was significantly higher in the JIA-patients compared to the healthy controls (p=0.016). The patients also had lower total arterial compliance (C) (p=0.022), but the arterial resistance (R) was not different (p= 0.564). The heart rate was higher in the patients than in the controls (p=0.043), but the blood pressure did not differ between the groups (p=0.443, p=0.535).
Conclusion:
In spite of similar blood pressure, JIA patients have stiffer proximal aorta and lower total arterial compliance than matched controls. This indicates that JIA-patients with long term active disease experience significant alteration of arterial function.
Table
|
Variables |
JIA-patients Mean ± SD |
Controls Mean ± SD |
P-value (unpaired t-test) |
|
BMI |
25.7 ± 4.9 |
25.3 ± 4.0 |
0.785 |
|
Systolic blood pressure (mmHg) |
117 ±15 |
114 ±11 |
0.443 |
|
Diastolic blood pressure (mmHg) |
69 ± 9 |
68 ± 9 |
0.535 |
|
Heart rate (beats/s) |
67 ± 11 |
60 ± 8 |
0.043 |
|
Cardiac output( l min -1) |
5.3 ± 1.1 |
5.3 ± 0.9 |
0.982 |
|
R (mmHg/(ml/s)) |
1.04 ± 0.21 |
1.00 ± 0.23 |
0.564 |
|
Z0 Windkessel Model (WK) (10^-3 mmHg/ml/s) |
77 ± 25 |
58 ± 20 |
0.016 |
|
C Pulse pressure method (PPM) (ml/mmHg) |
1.21 ± 0.24 |
1.44 ± 0.34 |
0.022 |
Disclosure:
H. Aulie,
None;
M. E. Estensen,
None;
A. M. Selvaag,
None;
P. Segers,
None;
O. Molberg,
None;
V. Lilleby,
None;
S. Aakhus,
None;
B. Flatø,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/increased-arterial-stiffness-in-juvenile-idiopathic-arthritis-jia-patients-compared-with-matched-controls-a-pilot-study/