Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose: The assessment of disease activity in rheumatology is essential in both clinical trials and practice. The patient reported questionnaires have shown to reflect disease activity appropriately and is especially feasible in busy clinical settings. On the other hand, distribution of multiple questionnaires to patients with different diseases in a reception area might be difficult. A single questionnaire regarding to disease activity for all rheumatic diseases may present advantages to introduce quantitative measurement into routine care. Recently, a questionnaire that has been widely used and validated for rheumatoid arthritis, routine assessment of patient index data 3 (RAPID3), consists of patient function, pain, and patient global assessment, and has been suggested as suitable index for all rheumatic diseases. The aim of this study was to evaluate correlation of RAPID3 with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), AS Disease Activity Score (ASDAS), Bath AS Functional Index (BASFI), patient global assessment (PGA), and physician’s global assessment (PhGA) in AS patients.
Methods: This single-centre, cross-sectional study was performed in a rheumatology department at a tertiary-care hospital. We included 341 consecutive AS patients who met the modified New York classification criteria. All patients completed BASDAI, BASFI, and MDHAQ at each visit, and their physicians completed physician global assessment. ASDAS scores were calculated using defined formulas. Spearman’s rho correlation test was used to determine the linear association between RAPID3 and other disease activity measures.
Results: The median age of AS patients was 34.0 (21.0-69.0) years and the median disease duration 10.0 (2.0-35.0) years; 273 patients (80.1%) were male. Median scores for RAPID3, BASDAI, BASFI, ASDAS-CRP, ASDAS-ESR, PGA and PhGA were 13.0 (0.0-27.3), 4.7 (0.0-9.7), 3.0 (0.0-9.4), 3.0 (0.4-5.8), 2.5 (0.5-6.3), 5.0 (0.0-10.0) and 3.5 (0.0-9.5), respectively. RAPID3 was strongly correlated with PGA, BASDAI, and ASDAS-ESR (r=0.843, r=0.842, r=0.815; p<0.001, respectively) (Table 1).
Conclusion:
RAPID3 was found to have good levels of positive correlation with BASDAI, BASFI, ASDAS-CRP, ASDAS-ESR, PGA and PhGA and seems to be as informative as those established disease activity indices. One might conclude that this index can be replaced for them in the follow-up patients with AS and it may offer an additional advantage of being easier to implement in a routine care setting.
Tablo 1 Correlation analysis between all disease activity measures.
|
|
PhGA |
PGA |
ASDAS-ESR |
ASDAS-CRP |
BASFI |
BASDAI |
|
RAPID3 |
0.637 |
0.843 |
0.815 |
0.790 |
0.793 |
0.842 |
|
BASDAI |
0.581 |
0.796 |
0.828 |
0.829 |
0.764 |
|
|
BASFI |
0.545 |
0.737 |
0.717 |
0.673 |
|
|
|
ASDAS-CRP |
0.672 |
0.824 |
0.888 |
|
|
|
|
ASDAS-ESR |
0.718 |
0.821 |
|
|
|
|
|
PGA |
0.606 |
|
|
|
|
|
Disclosure:
M. Cinar,
None;
S. Yilmaz,
None;
F. I. Cinar,
None;
S. S. Koca,
None;
H. Erdem,
None;
S. Pay,
None;
Y. Yazici,
None;
A. Dinc,
None;
I. Simsek,
None.
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