ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 383

Increased Incidence Of Low-Energy Fractures In Rheumatoid Arthritis Patients

Kristina Wiberg1, Marie-Louise Öhman2, Ulrika Bergström3 and Solbritt M. Rantapaa-Dahlqvist4, 1Institution of Public Helath & Clinical Medicin, Rheumatology, Umeå University, Umeå, Sweden, 2Institution of Public Health & Clinical Medicin, Rheumatology, Umeå University, Umeå, Sweden, 3Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden, 4Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Umeå, Sweden, Umea, Sweden

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords:

Session Information

Title: Rheumatoid Arthritis - Clinical Aspects I: Comorbidities in Rheumatoid Arthritis

Session Type: Abstract Submissions (ACR)

Background/Purpose:

Patients with rheumatoid arthritis (RA) have increased development of osteoporosis. The fracture indicence is not well explored. The aim of this study was to estimate the incidence of low-energy fractures in RA patients identified with a population based register of fractures in northern Sweden.

Methods:

The register of patients with RA (ACR criteria) consecutively included since 1995 (n=1178) was coanalysed with the register of Umeå injury data base, Umeå, Sweden of low-energy fractures. This data base was constituted in 1993 and covers six communities with a population at risk of 118000 adults.  All individuals admitted to the emergency ward are included. The individuals in this study were followed until fracture or to Jan 1st2011. The standard incidence ratio (SIR) was calculated.

Results:

Among the RA patients, 329 individuals (246 females and 83 males) were identified with a fracture. The corresponding figures among controls were 14102 females and 13313 males with fractures. The SIR for a fracture in the RA patients was overall in females OR=1.35 (1.19-1.53) and in males OR=1.70 (1.36-2.11). Stratification for age showed increased SIR in the year group over 65 years of age; females OR=1.39 (1.19-1.62) and males OR=1.88 (1.44-2.42). The highest SIR was for hip fracture; females OR=2.51 (1.21-4.61) and males OR=4.75 (1.74-10.35) with a similar mean age for cases and controls; 72-75 years. The duration of time from diagnosis of RA to the first fracture was during the follow up in females mean (SD) 16.9 (12.4) years and in males 11.7 (9.9) years. The RA patients had similar frequence of fractures in- as out-doors as compared with controls who had significantly higher frequency of fractures outdoors.

Conclusion:

RA is associated with a higher incidence for fractures among individuals seeking emergency care. In this study the highest SIR was for hip fractures both in females and males.

Disclosure:

K. Wiberg,
None;

M. L. Öhman,
None;

U. Bergström,
None;

S. M. Rantapaa-Dahlqvist,
None.

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