Session Information
Session Type: Poster Session A
Session Time: 10:30AM-12:30PM
Background/Purpose: Cerebrovascular diseases are common and severe neurological complications in antiphospholipid syndrome (APS). However, few studies focused on cerebral small vessel disease (cSVD) in APS. We undertook this study to investigate the subtypes, the total burden on MRI and potential risk factors for cSVD in APS.
Methods: We retrospectively analyzed the medical records and brain magnetic resonance imaging (MRI) scans of patients with APS who visited our hospital between January 2015 and July 2022. An age and gender-matched healthy control group were recruited from the Health Care Center affiliated with Peking University People’s Hospital. Four major cSVD markers on MRI were assessed, including lacune, enlarged perivascular space (EPVS), microbleed and white matter hyperintensities (WMH). Total cSVD score, ranging from 0 to 4, were rated using validated visual scales. Univariate and multivariate logistic regression model was applied to analyze the association between clinical and laboratory indices and cSVD risks in APS.
Results: Among 132 enrolled patients, 76.5% (101/132) were females with a mean age of 47.0 years. 26.5% (35/132) were primary APS, and 51.5% (68/132) exhibited at least one of the cSVD markers. Lacune was the most frequent cSVD marker [46.2% (61/132)], followed by moderate-to-severe WMH [16.7% (22/132)], EPVS [14.4% (19/132)] and microbleed [12.1% (16/132)]. After adjusting for age, gender and disease duration, the cSVD was significantly associated with hypertension (OR 3. 688, 95%CI 1.17-11.65, P = 0.026), the incidence of thrombosis events (OR 22.145, 95%CI 2.11-232.27, P = 0.010), and the history of stroke (OR 10.709, 95%CI 2.47-46.36, P = 0.002).
Conclusion: In the present study, we observed a high incidence of cSVD in patients with APS. Hypertension, thrombotic events and the history of stroke are risk factors for cSVD in APS.
To cite this abstract in AMA style:
Li C, Guo J, Fan Y, Kang Y, Hu X. Cerebral small vessel disease in antiphospholipid syndrome: subtypes and total burden of cSVD on MRI [abstract]. Arthritis Rheumatol. 2025; 77 (suppl 9). https://acrabstracts.org/abstract/cerebral-small-vessel-disease-in-antiphospholipid-syndrome-subtypes-and-total-burden-of-csvd-on-mri/. Accessed .« Back to ACR Convergence 2025
ACR Meeting Abstracts - https://acrabstracts.org/abstract/cerebral-small-vessel-disease-in-antiphospholipid-syndrome-subtypes-and-total-burden-of-csvd-on-mri/