The Relationship Between First-Trimester Maternal Serum 25-Hydroxyvitamin D and Maternal/Fetal Outcomes in Patients with Systemic Lupus Erythematosus

wen zeng¹, Yuanyuan zeng¹, Lan Zhang², Cheng Zhao¹, Fang Qin¹, Leting Zheng², Mu Huang² and ling lei¹, ¹The First Affiliated Hospital of Guangxi Medical University, nanning, China (People's Republic), ²The First Affiliated Hospital of Guangxi Medical University, nanning, Guangxi, China (People's Republic)

Meeting: ACR Convergence 2024

Keywords: pregnancy, Systemic lupus erythematosus (SLE)

Session Information

Date: Monday, November 18, 2024

Title: SLE – Diagnosis, Manifestations, & Outcomes Poster III

Session Type: Poster Session C

Session Time: 10:30AM-12:30PM

Background/Purpose: To identify whether serum 25-Hydroxyvitamin D (25(OH)D) level in first-trimester(before13 weeks of gestation) maternal is associated with pregnancy outcomes in patients with systemic lupus erythematosus (SLE).

Methods: A retrospective analysis of 199 pregnancies in 185 patients was conducted to analyze the relationship between maternal and fetal outcomes and 25(OH)D level in first -trimester maternal.

Results: In total, the mean age at conception was 30±4.7 years, the mean SLE duration was 4.50±2.78 years. Forty-two (21.1%) patients had 25(OH)D deficiency, seventy-eight (39.1%) patients had 25(OH)D insufficiency, and seventy-nine(39.6%) patients were 25(OH)D sufficiency. One hundred and four patients with adverse pregnancy outcomes (52.2%). Among maternal outcomes, 16 (8.0%) had pregnancy-induced hypertension, 10 (5.0%) had eclampsia, and 34 (17.0%) had flare-ups. Of the fetal outcomes, 59 (29.6%) had pregnancy loss, 26 (13.0%) had preterm birth, and 40 (28.5%) had low birth weight. Regression analysis shows that 25(OH)D deficiency and insufficiency were risk factors for low birth weight (LBW)(deficiency: unadjusted OR = 4.510, 95% CI 1.421-14.313, P = 0.011; adjusted OR = 5.599, 95% CI 1.143- 14.743 P = 0.007; insufficiency: unadjusted OR = 4.973, 95% CI 1.841-13.434, P = 0.002; adjusted OR = 8.312, 95% CI 2.413-28.635 P = 0.001).

Conclusion: 25(OH)D deficiency and insufficiency in early pregnancy in lupus patients were associated with the risk of LBW

Baseline characteristics of pregnant patients with SLE (N= 199)

Pregnancy outcomes stratified by maternal 25(OH)D status in first trimester (N= 199)

TABLE 3 Unadjusted and adjusted odds ratios for maternal and infant stratified by 25(OH)D status(Using 25(OH)D sufficiency (> 75 nmol/L) as a reference).

Disclosures: w. zeng: None; Y. zeng: None; L. Zhang: None; C. Zhao: None; F. Qin: None; L. Zheng: None; M. Huang: None; l. lei: None.

To cite this abstract in AMA style:

zeng w, zeng Y, Zhang L, Zhao C, Qin F, Zheng L, Huang M, lei l. The Relationship Between First-Trimester Maternal Serum 25-Hydroxyvitamin D and Maternal/Fetal Outcomes in Patients with Systemic Lupus Erythematosus [abstract]. Arthritis Rheumatol. 2024; 76 (suppl 9). https://acrabstracts.org/abstract/the-relationship-between-first-trimester-maternal-serum-25-hydroxyvitamin-d-and-maternal-fetal-outcomes-in-patients-with-systemic-lupus-erythematosus/. Accessed .

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