Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose: Although the etiology of inflammatory myopathies is unclear, there are data indicating that myositis occurs as a result of complex interactions between genes and environmental/life style factors.
The aim of this study was to assess the association between lung disease and the risk of developing inflammatory myopathies, myositis.
Methods: In this population-based case-control study, 179 incident adult myositis cases diagnosed between 1995 and 1997 were identified from the Swedish inpatient registry. Verification of diagnosis was performed through patient records. The analysis was based on responses from a questionnaire on exposures to environmental factors from 100 cases that were alive and fulfilled the inclusion criteria and from 402 randomly selected population controls matched to cases on birth of date, gender and residency. Exposure was based upon self-reports of preceding inflammatory lung disease (pneumonia, tuberculosis or sarcoidosis). The association between inflammatory lung disease and risk of developing myositis was evaluated by calculating odds ratio (OR) together with 95% confidence interval (CI) by means of logistic regression.
Results:
There was a suggestive association between preceding inflammatory lung disease and diagnosis of myositis: adjusted OR = 1,5 (CI (95%) = 0.9-2.6). The number of cases and controls that reported inflammatory lung disease (i.e. pneumonia, tuberculosis or sarcoidosis) was 42 (42%) and 112 (28%), respectively. Overall recorded signs of ILD were found in 16% of the cases, mainly based on results from chest radiography. Out of 12 cases with ILD, nine (75%) had reported inflammatory lung disease in the questionnaire, while the corresponding frequency for cases without ILD was 36%. The median duration between the lung disease and first symptom of myositis was 30 years.
Conclusion: Subjects with a history of a preceding inflammatory lung disease had an increased risk to develop myositis compared to those without such disease. Inflammatory lung disease could thus be a potential risk factor for onset of inflammatory myopathies, in particular for the subset of patients with ILD, or it may be a parallel phenomenon.
Disclosure:
I. E. Lundberg,
BMS,
2,
Novartis Pharmaceutical Corporation,
5;
S. Barbasso Helmers,
None;
L. Alfredsson,
None.
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