Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose: To evaluate the diagnostic ability of the 2010 ACR/EULAR classification criteria for Rheumatoid arthritis (RA) in a consecutive series of elderly onset (> 50y) RA (EORA) in comparison with a group of new onset polymyalgia rheumatica (PMR) patients.
Methods: All patients with early arthritis seen at our two centres are followed according to a standardized protocol which include clinical examination (including 66 joint count), determination of laboratory parameters, QOL questionnaire, X-ray examination of hands and feet. Consecutive patients seen in our rheumatological centres with recent onset arthritis and followed for at least 12 months were included prospectively during a 5 year period. Patients entered the study if diagnosis of RA or PMR were confirmed at 12 month follow-up period according to rheumatologist opinion (PM, GB). Diagnostic performance of ACR/EULAR 2010 classification criteria were evaluated and compared in the two groups of patients
Results: 144 new EORA and 137 new onset PMR patients entered the study. Table 1 compare demographic, clinical and laboratory data between the two populations.
Conclusion: In a group of new onset EORA patients ACR/EULAR 2010 RA classification criteria have 66.2% sensitivity. ACR/EULAR 2010 criteria have high specificity and could be used to exclude RA in a new onset PMR patients
|
Table 1. Demographic, clinical and laboratory characteristics of the patients at first examination. |
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|
|
EORA |
PMR |
p |
Difference (95%CI) |
|
Mean Age (y) |
64.6+9.2 |
74.5+7.4 |
< 0.001 |
9.4(7.5-11.4) |
|
Male/female |
27/73 |
29/71 |
ns |
|
|
Mean Disease duration (Weeks) |
13+12 |
13+19 |
ns |
0.7(-4.6-3.2) |
|
ESR (mm/first hour) |
41+26 |
60+24 |
< 0.001 |
18 (12-24) |
|
CRP (mg/dl) |
2.5+3.2 |
5.1+4.3 |
< 0.001 |
2.5 (1.6-3.4) |
|
RF/ACPA + |
49% |
1% |
< 0.001 |
|
|
|
|
|
|
|
|
Mean large joint involved |
1.6+1.7 |
3.38+1 |
< 0.001 |
1.7(1.5-2) |
|
Mean small Joint Involved |
7.4+5.6 |
1+1 |
< 0.001 |
6.5(7.5-5.5) |
|
Mean ACR/EULAR points |
6.3+1.9 |
3.4+1 |
< 0.001 |
3 (3.3-2.4) |
|
ACR/EULAR positivity |
66.2% |
3.2% |
< 0.001 |
OR 48.9 (14-163) |
Disclosure:
P. Macchioni,
None;
G. Barausse,
None;
L. Boiardi,
None;
G. Pazzola,
None;
R. Bortolotti,
None;
G. Restuccia,
None;
M. G. Catanoso,
None;
G. Paolazzi,
None;
C. Salvarani,
None.
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